A9202

Angiotensin Fragment 1-7 acetate salt hydrate

≥90% (HPLC), powder

• Empirical Formula (Hill Notation): C₄₁H₆₂N₁₂O₁₁ · xC₂H₄O₂ · yH₂O
• Molecular Weight: 899.00 (anhydrous free base basis)
• MDL number: MFCD00153513
• PubChem Substance ID: 24891425

Properties

• Quality Level: 200
• Assay: ≥90% (HPLC)
• form: powder
• UniProt accession no.: P01019
• storage temp.: −20°C
• SMILES string: CCC(C)C(NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(NC(=O)C(CCCNC(N)=N)NC(=O)C(N)CC(O)=O)C(C)C)C(=O)NC(Cc2cnc[nH]2)C(=O)N3CCCC3C(O)=O
• InChI: 1S/C41H62N12O11/c1-5-22(4)33(38(61)50-29(17-24-19-45-20-47-24)39(62)53-15-7-9-30(53)40(63)64)52-36(59)28(16-23-10-12-25(54)13-11-23)49-37(60)32(21(2)3)51-35(58)27(8-6-14-46-41(43)44)48-34(57)26(42)18-31(55)56/h10-13,19-22,26-30,32-33,54H,5-9,14-18,42H2,1-4H3,(H,45,47)(H,48,57)(H,49,60)(H,50,61)(H,51,58)(H,52,59)(H,55,56)(H,63,64)(H4,43,44,46)
• InChI key: PVHLMTREZMEJCG-UHFFFAOYSA-N
• Gene Information: human ... AGT(183)

Description

Amino Acid Sequence

Asp-Arg-Val-Tyr-Ile-His-Pro

Application

Angiotensin Fragment 1-7 acetate salt hydrate has been used:

• to evaluate its effects on a rat model of ventilator-induced diaphragmatic dysfunction (VIDD) with neuromuscular blocking agent infusion
• to unilaterally inject into the lateral preoptic area (LPA) to study its effects on intravesical pressure, arterial pressure, heart rate, and renal conductance in the female rats
• to study its association with influenza A virus (IAV) infection

Biochem/physiol Actions

Angiotensin fragment 1-7 is a biologically active heptapeptide of the renin-angiotensin system (RAS). It is associated with anti-inflammatory and anti-fibrotic effects in many inflammatory diseases such as asthma, dyslipidemia, renal injury, arthritis, and lung fibrosis. Angiotensin fragment 1-7 acts as a pro-resolving mediator and induces resolution of inflammation via Mas receptor (MasR). It is responsible for relaxation in several vascular beds. Angiotensin fragment 1-7 has a dual action of an angiotensin II type 1 (AT1) receptor agonist and antagonist depending on the presence of angiotensin II. It also serves as a substrate for angiotensin-converting enzyme (ACE). Sometimes, angiotensin fragment 1-7 prevents ACE activity leading to decreased angiotensin II generation and improved bradykinin-induced vasodilatation.

Other Notes

Lyophilized from 0.5% acetic acid

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves