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A9850

Sigma-Aldrich

Monoclonal Anti-Angiogenin antibody produced in mouse

clone 14017, purified immunoglobulin, lyophilized powder

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Synonym(s):
Anti-ANG
MDL number:
MFCD03792409
NACRES:
NA.41

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

14017, monoclonal

form

lyophilized powder

species reactivity

human

technique(s)

capture ELISA: 2-8 μg/mL
western blot: 1-2 μg/mL

isotype

IgG1

UniProt accession no.

P03950

storage temp.

−20°C

Gene Information

human ... ANG(283)

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Monoclonal Anti-ACE antibody produced in mouse clone 4B10, purified immunoglobulin, buffered aqueous solution

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conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody form

affinity isolated antibody

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

clone

14017, monoclonal

clone

polyclonal

clone

171718, monoclonal

clone

4B10, monoclonal

form

lyophilized powder

form

lyophilized powder

form

-

form

buffered aqueous solution

species reactivity

human

species reactivity

human

species reactivity

human

species reactivity

human

General description

Angiogenin (ANG) is a member of the ribonuclease superfamily that regulates blood vessel formation. ANG also modulates motor neuron physiology and the secretion of prostacyclin in endothelial cells. Mutations in ANG have been associated with amyotrophic lateral sclerosis . Monoclonal anti-angiogenin antibody is specific for recombinant human angiogenin.

Immunogen

purified recombinant human angiogenin expressed in E. coli.

Application

Monoclonal anti-angiogenin antibody is suitable for use in capture ELISA (2-8 μg/mL), immunoblot and western blot (1-2 μg/ml).
Monoclonal mouse anti-angiogenin was used for detection of angiogenin-I in mouse livers following induced myocardial ischemia by immunohistochemistry at a dilution of 1:1000.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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M Moenner et al.
European journal of biochemistry, 226(2), 483-490 (1994-12-01)
Angiogenin is a secreted polypeptide that induces neovascularization in vivo. The expression of angiogenin by human cells in culture was investigated by using a specific radioimmunoassay and by cDNA hybridization. Angiogenin immunoreactivity was widely but differentially produced by anchorage-dependent growing
Jian-Xiong Chen et al.
Diabetes, 57(12), 3335-3343 (2008-10-07)
Diabetic impaired angiogenesis is associated with impairment of hypoxia-inducible factor-1alpha (HIF-1alpha) as well as vasculature maturation. We investigated the potential roles and intracellular mechanisms of angiopoietin-1 (Ang-1) gene therapy on myocardial HIF-1alpha stabilization and vascular maturation in db/db mice. db/db
R Bicknell et al.
Proceedings of the National Academy of Sciences of the United States of America, 86(5), 1573-1577 (1989-03-01)
Angiogenin stimulates capillary and umbilical vein endothelial cell prostacyclin secretion but not that of prostaglandins of the E series. The response was quantitated by radioimmunoassay and by [3H]arachidonate labeling followed by analysis of the secreted prostaglandins. The stimulated secretion lasts
Aditya K Padhi et al.
PloS one, 7(2), e32479-e32479 (2012-03-03)
Mutations in the coding region of angiogenin (ANG) gene have been found in patients suffering from Amyotrophic Lateral Sclerosis (ALS). Neurodegeneration results from the loss of angiogenic ability of ANG (protein coded by ANG). In this work, we performed extensive

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