A9883

Sigma-Aldrich

ADA

≥98% (titration)

Synonym(s):
N-(Carbamoylmethyl)iminodiacetic acid, N-(2-Acetamido)iminodiacetic acid
Linear Formula:
H2NCOCH2N(CH2CO2H)2
CAS Number:
Molecular Weight:
190.15
Beilstein/REAXYS Number:
1787181
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.25
Pricing and availability is not currently available.

assay

≥98% (titration)

form

powder

pH

1.5-3.0

useful pH range

6.0 - 7.2

pKa (25 °C)

6.6

mp

219 °C (dec.) (lit.)

solubility

1 M NaOH: 160 mg/mL, clear, colorless

Featured Industry

Diagnostic Assay Manufacturing

storage temp.

room temp

SMILES string

NC(=O)CN(CC(O)=O)CC(O)=O

InChI

1S/C6H10N2O5/c7-4(9)1-8(2-5(10)11)3-6(12)13/h1-3H2,(H2,7,9)(H,10,11)(H,12,13)

InChI key

QZTKDVCDBIDYMD-UHFFFAOYSA-N

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General description

ADA is a zwitterionic buffer used in biochemistry and molecular biology. It is one of the Good buffers developed in the 1960′s to provide buffers in the pH range of 6.15 - 8.35 for wide applicability to biochemical studies. The pioneering publication by Good and co-workers describes the synthesis of ADA and its physical properties. The useful range of ADA buffer in aqueous solution is 6.0 - 7.2.

Packaging

100, 250 g in poly bottle
1 kg in poly bottle

Application

Biological buffer component with sodium hydroxide and sodium chloride (pH 5.67-7.57, useful pH range 6.4-7.4). Used to prepare immobilized pH gradients.

Preparation Note

This product is soluble in 1 M NaOH (160mg/mL), yielding a clear, colorless solution.

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Hydrogen ion buffers for biological research
Good NE, et al.
Biochemistry, 5( (2), 467-477 (1966)
Gulen Yesilbag Tonga et al.
Nature chemistry, 7(7), 597-603 (2015-06-24)
Bioorthogonal catalysis broadens the functional possibilities of intracellular chemistry. Effective delivery and regulation of synthetic catalytic systems in cells are challenging due to the complex intracellular environment and catalyst instability. Here, we report the fabrication of protein-sized bioorthogonal nanozymes through...
Johannan F Brandse et al.
Journal of Crohn's & colitis, 9(11), 973-981 (2015-06-28)
High serum concentrations of infliximab [IFX] and adalimumab [ADA] may be associated with adverse effects in patients with inflammatory bowel disease [IBD]. We aimed to investigate whether high anti-tumour necrosis factor [TNF] trough levels [TLs] were associated with toxicity and...
Harold Bays et al.
The Journal of clinical endocrinology and metabolism, 100(8), 3140-3148 (2015-06-02)
Despite current standard of care, many patients at high risk of cardiovascular disease (CVD) still have elevated low-density lipoprotein cholesterol (LDL-C) levels. Alirocumab is a fully human monoclonal antibody inhibitor of proprotein convertase subtilisin/kexin type 9. The objective of the...
D M Bers et al.
The American journal of physiology, 260(5 Pt 1), C900-C909 (1991-05-01)
Extracellular Ca (Cao) depletions that occur during cardiac muscle contractions are indicative of net Ca entry. Buffering Cao concentration ([Ca]o) with citrate can limit the magnitude of these Cao depletions [e.g., Shattock and Bers. Am. J. Physiol. 256 (Cell Physiol....

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