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AC-0062

Sigma-Aldrich

CD61 (GPIIIa) (EP65) Rabbit Monoclonal Primary Antibody

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NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

Ig fraction of antiserum

clone

monoclonal

form

buffered aqueous solution

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:200

shipped in

wet ice

storage temp.

2-8°C

visualization

(membrane/cytoplasm)

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This Item
161M-1131R-2123R-2
antibody form

Ig fraction of antiserum

antibody form

culture supernatant

antibody form

culture supernatant

antibody form

culture supernatant

clone

monoclonal

clone

2f2, monoclonal

clone

EP78, monoclonal

clone

EP75, monoclonal

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:200

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500 (concentrated)

General description

CD61, also known as GPIIIa and Integrin beta-3, is a glycoprotein encoded by the ITGB3 gene. CD61 heterodimerize with other cluster of differentiation molecules resulting in transmembrane integrins, facilitating cell to cell interactions and signal transduction. CD61 combines with CD41 to form platelet glycoprotein IIb/IIIa that serves as a receptor for fibrinogen and fibronectin. Platelet activation causes a conformational change in the glycoprotein to bind soluble fibrinogen to from a platelet plug. Alternative, CD61 can heterodimerize with CD51 to form Integrin alpha V beta 3, a receptor for vitronectin and von Willebrand factor. CD61 is expressed in the membrane and cytoplasm of platelets and megakaryocytes across diverse tissue types. Endothelium is also stained. Most cases of acute megakaryoblastic leukemia (AML M7) are positive for CD61.

Quality


IVD

IVD

IVD

RUO

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and &lt0.1% Sodium Azide

Other Notes

For a copy of the IFU and CofA contact IVDorder@ABCAM.com

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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