AC-0365A

Claudin-7 (EP399) Rabbit Monoclonal Primary Antibody

• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 500
• antibody form: Ig fraction of antiserum
• clone: monoclonal
• description: For In Vitro Diagnostic Use in Select Regions (See Chart)
• form: buffered aqueous solution
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:200
• shipped in: wet ice
• storage temp.: 2-8°C
• visualization: membranous

Description

General description

The claudin family of epithelial tight junction proteins that play critical roles for cell-cell adhesion and maintenance of cellular polarity. Claudin members are expressed in a tissue specific manner; claudin-7 expression is localized to the distal nephron epithelium. Claudin-7 has been extensively studied in renal cell carcinoma (RCC) subtypes. By immunohistochemical (IHC) analysis, membranous claudin-7 expression was detected in 67% of chromophobe RCC, compared with 0% of clear cell RCCs, 28% of papillary RCCs, and 23% oncocytomas. Claudin-7 expression may provide clinical utility in the differential diagnosis of chromophobe RCC and oncocytoma. While both chromophobe RCC and oncocytoma are derived from intercalated cells of the cortical collecting duct, oncocytomas are typically benign lesions whereas chromophobe RCCs are potentially aggressive malignancies. These RCC subtypes can be difficult to differentiate by morphology alone. Hornsby and colleagues examined claudin-7 IHC and reported 71% and 73% positive and negative predictive values for the differential diagnosis of chromophobe RCC from oncocytoma.

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and &lt0.1% Sodium Azide

Analysis Note

IVD

IVD

IVD

RUO

Other Notes

For a copy of the IFU and CofA contact [email protected]

For Technical Service please contact: 800-665-7284 or email: [email protected]

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable