The immunogen for anti-CCL7 antibody: synthetic peptide derected towards the N terminal of human CCL7
Anti-CCL7 antibody produced in rabbit is suitable for western blotting at a concentration of 0.5 μg/ml. For immunohistochemistry of paraffin-embedded tissue sections, a concentration of 4-8 μg/ml is suitable.
CCL7 encodes monocyte chemotactic protein 3, a secreted chemokine which attracts macrophages during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. The protein is an in vivo substrate of matrix metalloproteinase 2, an enzyme which degrades components of the extracellular matrix. This gene is part of a cluster of C-C chemokine family members on chromosome 17q.
CCL7, also known as MCP3, is a CC chemokine that binds monocytes and has been shown to regulate macrophage activity.
Synthetic peptide located within the following region: TSTTCCYRFINKKIPKQRLESYRRTTSSHCPREAVIFKTKLDKEICADPT
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
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