AV48103

Sigma-Aldrich

Anti-MAPT antibody produced in rabbit

affinity isolated antibody

Synonym(s):
Anti-FTDP-17, Anti-Microtubule-associated protein tau, Anti-FLJ31424, Anti-MSTD, Anti-MGC138549, Anti-DDPAC, Anti-MAPTL, Anti-MTBT1
NACRES:
NA.41
Pricing and availability is not currently available.

biological source

rabbit

Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

46 kDa

species reactivity

human

concentration

0.5 mg - 1 mg/mL

application(s)

immunohistochemistry: suitable
western blot: suitable

conjugate

unconjugated

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... MAPT(4137)

General description

Microtubule-associated protein tau (MAPT) is a neuronal protein that is involved in cellular apoptosis and microtubule organization. Alterations in MAPT have been linked to neurodegenerative disorders such as Parkinson′s and Alzheimer′s disease.
Rabbit Anti-MAPT antibody recognizes human, mouse, and rat MAPT.

Immunogen

Synthetic peptide directed towards the middle region of human MAPT

Application

Rabbit Anti-MAPT antibody is suitable for western blot applications at a concentration of 0.5μg/ml.

Biochem/physiol Actions

MAPT is differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. The mutations in the gene have been associated with several neurodegenerative disorders such as Alzheimer′s disease, Pick′s disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer′s disease, Pick′s disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.

Sequence

Synthetic peptide located within the following region: RGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPG

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Atsushi Iwata et al.
Human molecular genetics, 23(3), 648-656 (2013-10-09)
The hallmark of Alzheimer's disease (AD) pathology is an accumulation of amyloid β (Aβ) and phosphorylated tau, which are encoded by the amyloid precursor protein (APP) and microtubule-associated protein tau (MAPT) genes, respectively. Less than 5% of all AD cases...
Lan Yu et al.
BMC neuroscience, 15, 54-54 (2014-05-02)
Microtubule-associated protein tau (MAPT) is a neuronal protein involved in the pathogenesis of several neurodegenerative diseases including Parkinson's Disease (PD). Glycogen synthase kinase 3 beta (GSK3B) catalyzes phosphorylation in multiple sites of tau protein. However, whether or not there is...

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