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B003

Sigma-Aldrich

Chloroethylclonidine dihydrochloride

solid

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Synonym(s):
2-[2,6-Dichloro(N-β-chloroethyl-N-methyl)-4-aminomethyl]phenylimino-2-imidazolidine dihydrochloride, CEC dihydrochloride
Empirical Formula (Hill Notation):
C13H17Cl3N4 · 2HCl
CAS Number:
Molecular Weight:
408.58
MDL number:
PubChem Substance ID:
NACRES:
NA.32

form

solid

color

off-white

solubility

0.1 M NaOH: 1 mg/mL (Stable for 24 hours at 4 °C.)
H2O: 12 mg/mL (Stable for 24 hours at 4 °C.)
methanol: 17 mg/mL (Stable for 24 hours at 4 °C.)
aqueous base: unstable

SMILES string

Cl.Cl.CN(CCCl)Cc1cc(Cl)c(\N=C2/NCCN2)c(Cl)c1

InChI

1S/C13H17Cl3N4.2ClH/c1-20(5-2-14)8-9-6-10(15)12(11(16)7-9)19-13-17-3-4-18-13;;/h6-7H,2-5,8H2,1H3,(H2,17,18,19);2*1H

InChI key

CZSAXNDACBPMAB-UHFFFAOYSA-N

Gene Information

human ... ADRA1B(147)

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Biochem/physiol Actions

Irreversible α1B-adrenoceptor alkylating agent.

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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G Leclerc et al.
British journal of pharmacology, 71(1), 5-9 (1980-01-01)
1 alpha-Adrenoceptor stimulant activity was determined for noradrenaline (NA), clonidine and a series of para-substituted derivatives of clonidine on rat aortic strips, a rat brain synaptosome preparation, and anaesthetized pithed rats. The effects on the blood pressure of intraventricular (i.c.v.)
L Xiao et al.
European journal of pharmacology, 347(2-3), 319-327 (1998-07-08)
We quantified and compared the rates at which chloroethylclonidine (CEC) inactivated cloned rat alpha1A, alpha1B-, and alpha1D-adrenoceptors. Membranes from cells transfected with one of the three cloned alpha1-adrenoceptors were incubated for various intervals with 100 microM chloroethylclonidine at 10 degrees
M Takanashi et al.
Naunyn-Schmiedeberg's archives of pharmacology, 343(6), 669-673 (1991-06-01)
The influence of the alpha 1b-adrenoceptor-selective antagonist chlorethylclonidine on the alpha 1-adrenergic positive inotropic effect and the phosphoinositide hydrolysis induced by phenylephrine was investigated in the rabbit ventricular myocardium. Pretreatment of membrane fractions derived from the rabbit ventricular muscle with
Yoav Litvin et al.
The European journal of neuroscience, 40(2), 2344-2351 (2014-05-28)
Research suggests a causal link between estrogens and mood. Here, we began by examining the effects of estradiol (E2 ) on rat innate and conditioned defensive behaviors in response to cat odor. Second, we utilized whole-cell patch clamp electrophysiological techniques

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