B0375

Barbital

Name: Barbital
Brand: SIGMA

Synonym(s):

5,5-Diethyl-2,4,6(1H,3H,5H)-pyrimidinetrione, 5,5-Diethylbarbituric acid, Barbitone, Veronal

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About This Item

Empirical Formula (Hill Notation):

C₈H₁₂N₂O₃

CAS Number:

57-44-3

Molecular Weight:

184.19

UNSPSC Code:

51361926

NACRES:

NA.21

PubChem Substance ID:

24891513

EC Number:

200-331-2

Beilstein/REAXYS Number:

163999

MDL number:

MFCD00036212

Key Documents

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SMILES string

CCC1(CC)C(=O)NC(=O)NC1=O

InChI

1S/C8H12N2O3/c1-3-8(4-2)5(11)9-7(13)10-6(8)12/h3-4H2,1-2H3,(H2,9,10,11,12,13)

InChI key

FTOAOBMCPZCFFF-UHFFFAOYSA-N

form

powder

drug control

USDEA Schedule IV; Home Office Schedule 3; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal); Pszichotróp anyag / Psychotropic Substance (Hungary), 78/2022. (XII. 28.) BM rendelet, kontrollierte Droge in Deutschland

Quality Level

200

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

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Analytical Chemistry

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Show Differences

1 of 4

This Item	31995	B0500	PHR8865
Sigma-Aldrich B0375 Barbital	Sigma-Aldrich 31995 Barbital	Sigma-Aldrich B0500 Sodium 5,5-diethylbarbiturate	Supelco PHR8865 Secobarbital
form powder	form -	form powder	form -
drug control USDEA Schedule IV; Home Office Schedule 3; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)	drug control USDEA Schedule IV; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)	drug control USDEA Schedule IV; Home Office Schedule 3; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)	drug control -
technique(s) HPLC: suitable	technique(s) HPLC: suitable, gas chromatography (GC): suitable	technique(s) HPLC: suitable, gas chromatography (GC): suitable	technique(s) -
application(s) forensics and toxicology pharmaceutical (small molecule) veterinary	application(s) forensics and toxicology pharmaceutical (small molecule) veterinary	application(s) forensics and toxicology pharmaceutical (small molecule) veterinary	application(s) pharmaceutical
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 300

Application

<ul>
<li><strong>Synthesis and characterization of some pyrimidine, purine, amino acid and mixed ligand complexes: </strong> This study explores the use of Barbital in the synthesis of various ligand complexes, highlighting its application in the development of life science reagents and pharmaceutical intermediates. This could inform R and D strategies for pharmaceutical manufacturing using Barbital as a key intermediate (Masoud et al., 2008).</li>
</ul>

Biochem/physiol Actions

Sedative/hypnotic

Legal Information

German
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.

English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.

pictograms

GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

pcodes

P264 - P270 - P301 + P312 - P501

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Synthesis and characterization of some pyrimidine, purine, amino acid and mixed ligand complexes.

Mamdouh S Masoud et al.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 69(1), 230-238 (2007-05-25)

Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) complexes of barbital, thiouracil, adenine, amino acids (methionine, lysine and alanine) and some mixed ligands were prepared and characterized by elemental analyses, IR, electronic spectra, magnetic susceptibility and ESR spectra. Coordination of

Multiwalled carbon nanotubes as a solid-phase extraction adsorbent for the determination of three barbiturates in pork by ion trap gas chromatography-tandem mass spectrometry (GC/MS/MS) following microwave assisted derivatization.

Haixiang Zhao et al.

Analytica chimica acta, 586(1-2), 399-406 (2007-03-28)

A new method was developed for the rapid screening and confirmation analysis of barbital, amobarbital and phenobarbital residues in pork by gas chromatography-tandem mass spectrometry (GC/MS/MS) with ion trap MSD. The residual barbiturates in pork were extracted by ultrasonic extraction

When blood transfusion medicine becomes complicated due to interference by monoclonal antibody therapy.

Marlies Oostendorp et al.

Transfusion, 55(6 Pt 2), 1555-1562 (2015-05-20)

Monoclonal antibodies (MoAbs) are increasingly integrated in the standard of care. The notion that therapeutic MoAbs can interfere with clinical laboratory tests is an emerging concern that requires immediate recognition and the development of appropriate solutions. Here, we describe that

Rapid ultraviolet monitoring of multiple psychotropic drugs with a renewable microfluidic device.

Jin Sheng et al.

Analytica chimica acta, 679(1-2), 1-6 (2010-10-19)

A rapid method for sensitive ultraviolet detection of multiple psychotropic drugs in human plasma was developed on a low-cost and expediently fabricated hybrid microfluidic device. The device was composed of one fused-silica capillary with a sampling fracture, a poly(methyl methacrylate)

Systemic and intracerebroventricular administration of sodium barbital induced a place preference in rats.

J M Bossert et al.

Behavioural pharmacology, 14(7), 517-523 (2003-10-15)

We have shown previously that 15 mg/kg pentobarbital induces a conditioned place preference (CPP), but it is unsuitable for intracranial administration. Since the long-acting barbiturate, sodium barbital, is soluble at a neutral pH, we tested whether it would induce a

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