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MilliporeSigma

B1401

Bradykinin Fragment 1-5

≥97% (HPLC)

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5 MG

$314.00

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About This Item

Empirical Formula (Hill Notation):
C27H40N8O6
CAS Number:
23815-89-6
Molecular Weight:
572.66
NACRES:
NA.32
PubChem Substance ID:
24891591
UNSPSC Code:
12352200
MDL number:
MFCD00076260
Form:
powder
Assay:
≥97% (HPLC)

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Product Name

Bradykinin Fragment 1-5, ≥97% (HPLC)

InChI

1S/C27H40N8O6/c28-18(9-4-12-31-27(29)30)24(38)35-14-6-11-21(35)25(39)34-13-5-10-20(34)23(37)32-16-22(36)33-19(26(40)41)15-17-7-2-1-3-8-17/h1-3,7-8,18-21H,4-6,9-16,28H2,(H,32,37)(H,33,36)(H,40,41)(H4,29,30,31)

SMILES string

NC(CCCNC(N)=N)C(=O)N1CCCC1C(=O)N2CCCC2C(=O)NCC(=O)NC(Cc3ccccc3)C(O)=O

InChI key

USSUMSBPLJWFSZ-UHFFFAOYSA-N

assay

≥97% (HPLC)

form

powder

UniProt accession no.

P01042

storage temp.

−20°C

Quality Level

200

Gene Information

human ... KNG1 (includes EG:3827)

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This Item
B1901I3400K1632
Bradykinin Fragment 1-5 ≥97% (HPLC)

Sigma-Aldrich

B1401

Bradykinin Fragment 1-5

Bradykinin Fragment 2-9 ≥97% (HPLC)

Sigma-Aldrich

B1901

Bradykinin Fragment 2-9

Interferon-γ-Inducible Protein-10 human ≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

Sigma-Aldrich

I3400

Interferon-γ-Inducible Protein-10 human

Kininogen high molecular weight, Two Chain from human plasma lyophilized powder

Sigma-Aldrich

K1632

Kininogen high molecular weight, Two Chain from human plasma

assay

≥97% (HPLC)

assay

≥97% (HPLC)

assay

≥97% (SDS-PAGE)

assay

-

form

powder

form

powder

form

lyophilized powder

form

lyophilized powder

Gene Information

human ... KNG1 (includes EG:3827)(3827)

Gene Information

human ... KNG1 (includes EG:3827)(3827)

Gene Information

human ... CXCL10(3627)

Gene Information

human ... KNG1(3827), KNG1 (includes EG:3827)(3827)

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

UniProt accession no.

P01042

UniProt accession no.

P01042

UniProt accession no.

P01579

UniProt accession no.

P01042

Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

200

Biochem/physiol Actions

The bradykinin (BK) fragment (1-5) (RPPGF) is among the most stable of naturally occurring metabolites. It may be used as a marker for BK production in vivo. It is known that an intact Arg residue in the C-terminus is required for biological activities. BK 1-5 is the minimal peptide that inhibited α-thrombin-induced platelet aggregation and secretion and calcium mobilization. It also prevented α-thrombin from cleaving the thrombin receptor peptide, NATLDPRSFLLR, between arginine and serine. Such antithrombin activities of BK 1-5 may contribute to the cardioprotective nature of kinins.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN6295
BCCG5734
BCBV6317
BCBR9832V
BCBM5382V

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Mitsuhiro Hirata et al.
British journal of pharmacology, 135(1), 29-36 (2002-01-12)
1. The involvement of bradykinin (BK) B(2) receptor in acute pancreatitis induced by pancreaticobiliary duct ligation was investigated in rats. 2. The activities of amylase and lipase in the serum, the water content of the pancreas, and vacuolization of the
S A Doggrell
Expert opinion on investigational drugs, 10(8), 1567-1569 (2002-01-12)
When the defence response of the body to infectious bacteria fails, septic shock ensues with hypotension and death. RPPGF,(1-5)-bradykinin, was until recently considered to be an active metabolite of bradykinin. In an animal model of septicaemia (lipopolysaccharide administration to rats)
Beata Bujak-Giżycka et al.
Acta biochimica Polonica, 58(2), 199-202 (2011-05-31)
Alterations in the formation and metabolism of bradykinin (Bk) are hypothesized to play a role in the pathophysiology of hypertension, atherosclerosis and vascular complications of diabetes. However, despite its prominent role in cardiovascular regulation, studies on bradykinin have been limited
Mias Pretorius et al.
Clinical pharmacology and therapeutics, 76(4), 379-387 (2004-10-08)
This study tested the hypothesis that angiotensin-converting enzyme (ACE) inhibitors potentiate activation of the kallikrein-kinin system during cardiopulmonary bypass (CPB). The effects of CPB on concentrations of bradykinin and its metabolite bradykinin 1-5 (BK1-5) were determined in 31 patients taking
Holly A Sawyer et al.
Journal of the American Society for Mass Spectrometry, 16(6), 893-905 (2005-05-10)
Ion mobility-mass spectrometry (IM-MS) data is interpreted as evidence that gas-phase bradykinin fragment 1-5 (BK1-5, RPPGF) [M + H](+) ions exist as three distinct structural forms, and the relative abundances of the structural forms depend on the solvent used to
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