B175

BW 723C86

Name: BW 723C86
Brand: SIGMA
Price: 250 USD
Availability: InStock

≥98% (HPLC)

Synonym(s):

α-methyl-5-(2-thienylmethoxy)-1H-Indole-3-ethanamine monohydrochloride

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10 MG

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$802.00

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Estimated to ship onMarch 27, 2026Details

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₁₈N₂OS · HCl

CAS Number:

160521-72-2

Molecular Weight:

322.85

NACRES:

NA.77

PubChem Substance ID:

24278284

UNSPSC Code:

12352200

MDL number:

MFCD01321066

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Key Documents

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InChI

1S/C16H18N2OS.ClH/c1-11(17)7-12-9-18-16-5-4-13(8-15(12)16)19-10-14-3-2-6-20-14;/h2-6,8-9,11,18H,7,10,17H2,1H3;1H

SMILES string

Cl.CC(N)Cc1c[nH]c2ccc(OCc3cccs3)cc12

InChI key

PYJBJMIBANAOFJ-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H₂O: 1 mg/mL, clear

Quality Level

100

Gene Information

human ... HTR2B(3357)

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Show Differences

1 of 4

This Item	SML0151	SML1714	SML2769
Sigma-Aldrich B175 BW 723C86	Sigma-Aldrich SML0151 CCT036477	Sigma-Aldrich SML1714 DCAI	Sigma-Aldrich SML2769 ASS234
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥95% (HPLC)	assay ≥98% (HPLC)
form powder	form powder	form powder	form powder
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
solubility H₂O: 1 mg/mL, clear	solubility DMSO: ≥20 mg/mL (warm to 60°C)	solubility DMSO: 20 mg/mL, clear	solubility DMSO: 2 mg/mL, clear
color white to beige	color white to tan	color white to brown	color white to beige
Gene Information human ... HTR2B(3357)	Gene Information -	Gene Information -	Gene Information -

Biochem/physiol Actions

5-HT_2B serotonin receptor agonist.

Disclaimer

Hygroscopic; photosensitive

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Effects of the 5-HT2B receptor agonist, BW 723C86, on three rat models of anxiety.

G A Kennett et al.

British journal of pharmacology, 117(7), 1443-1448 (1996-04-01)

1. BW 723C86 (3 and 10 mg kg-1, s.c. 30 min pretest), a 5-HT2B receptor agonist, increased total interaction, but not locomotion in a rat social interaction test, a profile consistent with anxiolysis. 2. The effect of BW 723C86 in

BW 723C86, a 5-HT2B receptor agonist, causes hyperphagia and reduced grooming in rats.

G A Kennett et al.

Neuropharmacology, 36(2), 233-239 (1997-02-01)

The 5-HT2B receptor agonist, BW 723C86 (10 and 20 mg/kg s.c.), increased the time spent in feeding behaviour of freely-fed rats in observation cages over 15 min. BW 723C86 (20 and 50 mg/kg s.c. 30 min pre-test) also modestly increased

Cross-talk inhibition between 5-HT2B and 5-HT7 receptors in phrenic motor facilitation via NADPH oxidase and PKA.

Raphael R Perim et al.

American journal of physiology. Regulatory, integrative and comparative physiology, 314(5), R709-R715 (2018-02-01)

Intermittent spinal serotonin receptor activation elicits phrenic motor facilitation (pMF), a form of spinal respiratory motor plasticity. Episodic activation of either serotonin type 2 (5-HT2) or type 7 (5-HT7) receptors elicits pMF, although they do so via distinct cellular mechanisms

Serotonin Is Involved in Autoimmune Arthritis through Th17 Immunity and Bone Resorption.

Yasmine Chabbi-Achengli et al.

The American journal of pathology, 186(4), 927-937 (2016-03-13)

Rheumatoid arthritis is a chronic disease that results in a disabling and painful condition as it progresses to destruction of the articular cartilage and ankylosis of the joints. Although the cause of the disease is still unknown, evidence argues that

Expression and function of serotonin 2A and 2B receptors in the mammalian respiratory network.

Marcus Niebert et al.

PloS one, 6(7), e21395-e21395 (2011-07-27)

Neurons of the respiratory network in the lower brainstem express a variety of serotonin receptors (5-HTRs) that act primarily through adenylyl cyclase. However, there is one receptor family including 5-HT(2A), 5-HT(2B), and 5-HT(2C) receptors that are directed towards protein kinase

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BW 723C86