B1760

Benzo[a]pyrene

≥96% (HPLC)

• Synonym(s): 3,4-Benzopyrene, 3,4-Benzpyrene, Benzo[def]chrysene
• Empirical Formula (Hill Notation): C₂₀H₁₂
• CAS Number: 50-32-8
• Molecular Weight: 252.31
• Beilstein: 1911333
• EC Number: 200-028-5
• MDL number: MFCD00003602
• PubChem Substance ID: 24891610

Properties

• Quality Level: 200
• Assay: ≥96% (HPLC)
• form: solid
• bp: 495 °C (lit.)
• mp: 177-180 °C (lit.)
• SMILES string: c1ccc2c(c1)cc3ccc4cccc5ccc2c3c45
• InChI: 1S/C20H12/c1-2-7-17-15(4-1)12-16-9-8-13-5-3-6-14-10-11-18(17)20(16)19(13)14/h1-12H
• InChI key: FMMWHPNWAFZXNH-UHFFFAOYSA-N

Description

Application

Benzo[a]pyrene (PAH), a polycyclic aromatic hydrocarbon pollutant, is used as a chemical carcinogen in experimental models of cancer. Carcinogenesis depends on it′s oxidation by CYP1A1 to benzo[a]pyrenediolepoxide, that forms depurinating adducts with DNA that dissociate to form abasic lesions. Benzo[a]pyrene is a ligand for the arylhydrocarbon receptor (AhR), and some of its biological effects, including the induction of CYP1A1, appear to be mediated via activation of the AhR.

Safety Information

• Pictograms: GHS07,GHS08,GHS09
• Signal Word: Danger
• Hazard Statements: H317 - H340 - H350 - H360FD - H410
• Precautionary Statements: P202 - P261 - P273 - P280 - P302 + P352 - P308 + P313
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Muta. 1B - Repr. 1B - Skin Sens. 1
• Storage Class Code: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3