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B2133

N-Benzoyl-Pro-Phe-Arg-p-nitroanilide hydrochloride

protease substrate, chromogenic, ≥97% (HPLC), powder

Synonym(s):

Bz-Pro-Phe-Arg-p-nitroanilide hydrochloride, Bz-Pro-Phe-Arg-pNA hydrochloride

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$255.00
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$2,600.00

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About This Item

Empirical Formula (Hill Notation):
C33H38N8O6 · HCl
CAS Number:
59188-28-2
Molecular Weight:
679.17
MDL number:
MFCD00039010
UNSPSC Code:
12352204
PubChem Substance ID:
24891630
NACRES:
NA.32

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Product Name

N-Benzoyl-Pro-Phe-Arg-p-nitroanilide hydrochloride, protease substrate

Quality Level

200

assay

≥97% (HPLC)

form

powder

solubility

methanol: 25 mg/mL

storage temp.

−20°C

SMILES string

Cl.NC(=N)NCCCC(NC(=O)C(Cc1ccccc1)NC(=O)C2CCCN2C(=O)c3ccccc3)C(=O)Nc4ccc(cc4)N(=O)=O

InChI

1S/C33H38N8O6.ClH/c34-33(35)36-19-7-13-26(29(42)37-24-15-17-25(18-16-24)41(46)47)38-30(43)27(21-22-9-3-1-4-10-22)39-31(44)28-14-8-20-40(28)32(45)23-11-5-2-6-12-23;/h1-6,9-12,15-18,26-28H,7-8,13-14,19-21H2,(H,37,42)(H,38,43)(H,39,44)(H4,34,35,36);1H

InChI key

OGYWLWIIQPDFPW-UHFFFAOYSA-N

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1 of 4

This Item
87528B7260T0273
N-Benzoyl-Pro-Phe-Arg-p-nitroanilide hydrochloride protease substrate

Sigma-Aldrich

B2133

N-Benzoyl-Pro-Phe-Arg-p-nitroanilide hydrochloride

Nα-Benzoyl-L-isoleucyl-L-glutamyl-glycyl-L-arginine-4-nitroanilide ≥97.0% (HPLC)

Sigma-Aldrich

87528

Nα-Benzoyl-L-isoleucyl-L-glutamyl-glycyl-L-arginine-4-nitroanilide

Nα-Benzoyl-L-arginine-7-amido-4-methylcoumarin hydrochloride protease substrate

Sigma-Aldrich

B7260

Nα-Benzoyl-L-arginine-7-amido-4-methylcoumarin hydrochloride

N-p-Tosyl-Gly-Pro-Arg 7-amido-4-methylcoumarin hydrochloride protease substrate

Sigma-Aldrich

T0273

N-p-Tosyl-Gly-Pro-Arg 7-amido-4-methylcoumarin hydrochloride

assay

≥97% (HPLC)

assay

≥97.0% (HPLC)

assay

≥99% (TLC)

assay

≥98% (TLC)

solubility

methanol: 25 mg/mL

solubility

-

solubility

DMSO:methanol (1:1): 20 mg/mL, clear, colorless

solubility

acetic acid: 10 mg/mL, clear, colorless

Quality Level

200

Quality Level

100

Quality Level

200

Quality Level

200

form

powder

form

powder

form

powder

form

powder

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

General description

A chromogenic substrate for Agkistrodon contortrix thrombin-like enzyme and plasma kallikrein.[1][2]

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000486957
0000486957
0000486756
0000486757
0000486757

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W Dick et al.
Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie, 19(6), 357-361 (1981-06-01)
A chromogenic assay for the determination of factor XII using the chromogenic substrate Chromozym PK was evaluated. The assay was linear in the range 10 U/l to more than 200 U/l. Using the assay, the normal range of factor XII
K Nishikawa et al.
Biochemical pharmacology, 43(6), 1361-1369 (1992-03-17)
Bradykinin (BK), an important mediator of allergic reactions and pain induction, is released by the activation of the plasma kallikrein-kinin (K-K) cascade. Neurotropin is a biological material obtained from inflamed rabbit skin inoculated with vaccinia virus and is widely used
G Claeson et al.
Haemostasis, 7(2-3), 62-68 (1978-01-01)
Chromogenic peptide substrates for serine proteases have been designed by using two approaches: (1) by using the natural substrate as a model and (2) by structure-activity correlations obtained through screening of a large number of tripeptides. Some recent examples, substrates
A V Nieuw Amerongen et al.
Biochimica et biophysica acta, 786(3), 245-251 (1984-05-17)
The previously isolated female submandibular glycoprotein AM1 ( Nieuw Amerongen , A.V., Vreugdenhil , A.P. and Roukema , P.A. (1977) Biochim. Biophys. Acta 495, 324-335) has been shown to have hydrolytic activity using N-alpha-benzoyl-L-arginine ethylester (BAEE) and ChromozymR PK as
G Vogel et al.
Folia haematologica (Leipzig, Germany : 1928), 109(1), 115-120 (1982-01-01)
The kallikrein specific chromogenic peptide substrates S-2302 (KABI) and Chromozym PK (Boehringer) were used in the first analysis of a familial defect in the early stage of clotting. Slight to extensive prolongation of the activated partial thromboplastin time was seen
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