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B3259

Sigma-Aldrich

Bradykinin acetate salt

powder, ≥98% (HPLC)

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Empirical Formula (Hill Notation):
C50H73N15O11 · xC2H4O2
CAS Number:
Molecular Weight:
1060.21 (free base basis)
EC Number:
NACRES:
NA.32

Quality Level

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white

solubility

0.1 M acetic acid: 25 mg/mL, clear, colorless

UniProt accession no.

storage temp.

−20°C

InChI

1S/C50H73N15O11/c51-32(16-7-21-56-49(52)53)45(72)65-25-11-20-39(65)47(74)64-24-9-18-37(64)43(70)58-28-40(67)59-34(26-30-12-3-1-4-13-30)41(68)62-36(29-66)46(73)63-23-10-19-38(63)44(71)61-35(27-31-14-5-2-6-15-31)42(69)60-33(48(75)76)17-8-22-57-50(54)55/h1-6,12-15,32-39,66H,7-11,16-29,51H2,(H,58,70)(H,59,67)(H,60,69)(H,61,71)(H,62,68)(H,75,76)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35-,36-,37-,38-,39-/m0/s1

InChI key

QXZGBUJJYSLZLT-FDISYFBBSA-N

Gene Information

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1 of 4

This Item
H4884S8758H7278
Bradykinin acetate salt powder, ≥98% (HPLC)

B3259

Bradykinin acetate salt

Hippuryl-His-Leu acetate salt

H4884

Hippuryl-His-Leu acetate salt

NG-Hydroxy-L-arginine acetate salt

H7278

NG-Hydroxy-L-arginine acetate salt

solubility

0.1 M acetic acid: 25 mg/mL, clear, colorless

solubility

acetic acid: 50 mg/mL, clear, colorless to very faintly yellow

solubility

50% acetic acid: 1 mg/mL, clear, colorless

solubility

acetic acid: 10 mg/mL, clear, colorless to faintly yellow

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98%

assay

≥98% (TLC)

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

200

storage condition

desiccated

storage condition

-

storage condition

-

storage condition

-

color

white

color

-

color

-

color

-

Amino Acid Sequence

Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg

Application

Bradykinin acetate salt has been used:
  • to stimulate the contraction of guinea pig ileum
  • as a contractile agent in fibroblasts
  • In the stimulation of endothelium of human subcutaneous artery
  • To evoke Ca2+ signals in neuroblastoma-glioma hybrid cell line, NG108-15

Biochem/physiol Actions

Bradykinin is a pro-inflammatory peptide that acts through G-protein-coupled receptors. It activates sphingolipid metabolism. Fibroblasts treated with bradykinin produce a rapid and important increase in ceramide which is followed by a transient rise in sphingosine content. The peptide also increases ceramide cellular content by rapidly mobilizing neutral glycolipids. Bradykinin plays an important role in the regulation of fluid and electrolyte balance, smooth muscle contraction, vasodilation and capillary permeability. The bradykinin potentiators, which possess no bradykinin activity themselves, enhance the activity of bradykinin.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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