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MilliporeSigma

B3503

Benzidine

≥98%

Synonym(s):

4,4′-Diaminobiphenyl

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About This Item

Empirical Formula (Hill Notation):
C12H12N2
CAS Number:
92-87-5
Molecular Weight:
184.24
UNSPSC Code:
12352116
NACRES:
NA.25
PubChem Substance ID:
24891724
EC Number:
202-199-1
Beilstein/REAXYS Number:
742770
MDL number:
MFCD00039765
Assay:
≥98%
Quality level:
200

Key Documents

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InChI key

HFACYLZERDEVSX-UHFFFAOYSA-N

InChI

1S/C12H12N2/c13-11-5-1-9(2-6-11)10-3-7-12(14)8-4-10/h1-8H,13-14H2

SMILES string

Nc1ccc(cc1)-c2ccc(N)cc2

Quality Level

200

Gene Information

human ... UGT1A4(54657)

assay

≥98%

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1 of 4

This Item
B338369301431614
Benzidine ≥98%

Sigma-Aldrich

B3503

Benzidine

Benzidine dihydrochloride ≥99% (titration)

Sigma-Aldrich

B3383

Benzidine dihydrochloride

(S)-H8-BINAP technical grade

Sigma-Aldrich

693014

(S)-H8-BINAP

Benzidine analytical standard

Supelco

31614

Benzidine

assay

≥98.0% (N)

assay

≥99% (titration)

assay

-

assay

-

form

powder

form

powder

form

powder

form

-

Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

100

Gene Information

human ... UGT1A4(54657)

Gene Information

-

Gene Information

-

Gene Information

-

Application

Benzidine (4,4′-Diaminobiphenyl) is an environmental genotoxin that posses increased risks of cancer to exposed people. Benzidine may be used as a reference material in procedures that analyze for benzidine. Benzidine can be used in studies on its mechanisms of genotoxicity.

Biochem/physiol Actions

Initiates tumors in the bladder under experimental conditions.[1]

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
SLCP3774
SLCM8603
SLCN5254
SLCQ1865
SLBF8865V

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Benzidine: a bladder carcinogen.
R G Wendel et al.
The Journal of urology, 111(5), 607-610 (1974-05-01)
Brian J Pak et al.
PLoS neglected tropical diseases, 8(8), e3002-e3002 (2014-08-08)
Strongyloidiasis is a persistent human parasitic infection caused by the intestinal nematode, Strongyloides stercoralis. The parasite has a world-wide distribution, particularly in tropical and subtropical regions with poor sanitary conditions. Since individuals with strongyloidiasis are typically asymptomatic, the infection can
Yaoyun Duan et al.
Cell death & disease, 10(10), 766-766 (2019-10-12)
The yolk sac is the first site of blood-cell production during embryonic development in both murine and human. Heat shock proteins (HSPs), including HSP70 and HSP27, have been shown to play regulatory roles during erythropoiesis. However, it remains unknown whether
J Whysner et al.
Pharmacology & therapeutics, 71(1-2), 107-126 (1996-01-01)
The aromatic amine benzidine (BZ) has produced various tumors, including liver tumors, in mice, rats and hamsters. BZ forms DNA adducts in rodent liver, and it is positive in most genotoxicity tests. Only bladder tumors are produced in dogs and
P D Josephy
Federation proceedings, 45(10), 2465-2470 (1986-09-01)
Benzidine oxidative activation may proceed by peroxidase-catalyzed one-electron oxidation via free radical intermediates, or by N-acetylation followed by monooxygenase-catalyzed N-hydroxylation. The peroxidase route has been examined by using horseradish peroxidase or prostaglandin H synthase in vitro. In the presence of
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