B4388

2-Bromo-2-chloro-1,1,1-trifluoroethane

≥99%

• Synonym(s): Halothane
• Linear Formula: BrCH(Cl)CF₃
• CAS Number: 151-67-7
• Molecular Weight: 197.38
• Beilstein: 1736947
• EC Number: 205-796-5
• MDL number: MFCD00009602
• PubChem Substance ID: 24891772
• NACRES: NA.77

Properties

• vapor pressure: 4.5 psi ( 20 °C)
• Quality Level: 200
• assay: ≥99%
• form: liquid
• contains: 0.01% thymol as stabilizer
• refractive index: n20/D 1.369 (lit.)
• bp: 50.2 °C (lit.)
• density: 1.872 g/mL at 25 °C (lit.)
• SMILES string: FC(F)(F)C(Cl)Br
• InChI: 1S/C2HBrClF3/c3-1(4)2(5,6)7/h1H
• InChI key: BCQZXOMGPXTTIC-UHFFFAOYSA-N
• Gene Information: human ... ATP5D(513) , GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879) , GLRA1(2741) , GLRB(2743) , GRIA1(2890) , KCNK10(54207) , KCNK18(338567) , KCNK2(3776) , KCNK3(3777) , KCNK9(51305) , KCNN4(3783)

Description

Application

2-Bromo-2-chloro-1,1,1-trifluoroethane, or halothane, has been used in a study that combined molecular simulations with free energy simulations to study solvation of halothane in polarizable water and methanol. Halothane has also been used in a study to investigate the interaction of anesthetics with the Rho GTPase regulator Rho GDP dissociation inhibitor.

Packaging

125, 250 mL in glass bottle

5, 50, 250 g

Biochem/physiol Actions

2-Bromo-2-chloro-1,1,1-trifluoroethane is an inhalation anesthetic. In an effect believed to be independent of anesthesia, halothane inhibits the synthesis of 5-hydroxytryptamine in brain tissue, probably at the tryptophan hydroxylase step.

Safety Information

• Pictograms: GHS05,GHS07,GHS08
• Signal Word: Danger
• Hazard Statements: H315 - H318 - H335 - H360
• Precautionary Statements: P202 - P261 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Eye Dam. 1 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves