Linear Formula:
CAS Number:
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PubChem Substance ID:

Quality Level

vapor pressure

4.5 psi ( 20 °C)




0.01% thymol as stabilizer

refractive index

n20/D 1.369 (lit.)


50.2 °C (lit.)


1.872 g/mL at 25 °C (lit.)

SMILES string




InChI key


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2-Bromo-2-chloro-1,1,1-trifluoroethane, or halothane, has been used in a study that combined molecular simulations with free energy simulations to study solvation of halothane in polarizable water and methanol. Halothane has also been used in a study to investigate the interaction of anesthetics with the Rho GTPase regulator Rho GDP dissociation inhibitor.


125, 250 mL in glass bottle

Biochem/physiol Actions

Inhalation anesthetic. In an effect believed to be independent of anesthesia, halothane inhibits synthesis of 5-hydroxytryptamine in brain tissue, probably at the tryptophan hydroxylase step.

Signal Word


Hazard Statements

Target Organs

Respiratory system

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves


UN 3334

WGK Germany


Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Mala Chakraborty et al.
Hepatology (Baltimore, Md.), 62(2), 546-557 (2015-02-26)
Clinical evidence suggests that many cases of serious idiosyncratic drug-induced liver injury are mediated by the adaptive immune system in response to hepatic drug-protein adducts, also referred to as "drug-induced allergic hepatitis"; but detailed mechanistic proof has remained elusive due...
Samina Salim et al.
Behavioural brain research, 208(2), 545-552 (2010-01-13)
Recent work has suggested correlation of oxidative stress with anxiety-like behavior. There also is evidence for anxiolytic effects of physical exercise. However, a direct role of oxidative stress in anxiety is not clear and a protective role of physical exercise...
G I Elmer et al.
Behavioural brain research, 359, 950-957 (2018-06-23)
A growing body of clinical and preclinical research suggests that structural and functional changes in the habenula, a component of the epithalamus, are associated with major depressive disorder. A major excitatory, efferent projection from the habenula targets the rostromedial tegmentum...
Jason T Moore et al.
Current biology : CB, 22(21), 2008-2016 (2012-10-30)
Despite seventeen decades of continuous clinical use, the neuronal mechanisms through which volatile anesthetics act to produce unconsciousness remain obscure. One emerging possibility is that anesthetics exert their hypnotic effects by hijacking endogenous arousal circuits. A key sleep-promoting component of...
T Russell et al.
Anaesthesia, 67(9), 1021-1024 (2012-06-28)
We present the case of a 20-year-old woman who developed rhabdomyolysis, disseminated intravascular coagulopathy and multi-organ failure induced by ecstasy. Following initial improvement, she developed delayed rhabdomyolysis then haloperidol-induced neuroleptic malignant syndrome, which was treated with a total of 50...

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