B4388

Sigma-Aldrich

2-Bromo-2-chloro-1,1,1-trifluoroethane

≥99%

Synonym(s):
Halothane
Linear Formula:
BrCH(Cl)CF3
CAS Number:
Molecular Weight:
197.38
Beilstein/REAXYS Number:
1736947
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

vapor pressure

4.5 psi ( 20 °C)

assay

≥99%

contains

0.01% thymol as stabilizer

refractive index

n20/D 1.369 (lit.)

bp

50.2 °C (lit.)

density

1.872 g/mL at 25 °C (lit.)

SMILES string

FC(F)(F)C(Cl)Br

InChI

1S/C2HBrClF3/c3-1(4)2(5,6)7/h1H

InChI key

BCQZXOMGPXTTIC-UHFFFAOYSA-N

Gene Information

human ... ATP5D(513), GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), GABRD(2563), GABRE(2564), GABRG1(2565), GABRG2(2566), GABRG3(2567), GABRP(2568), GABRQ(55879), GLRA1(2741), GLRB(2743), GRIA1(2890), KCNK10(54207), KCNK18(338567), KCNK2(3776), KCNK3(3777), KCNK9(51305), KCNN4(3783)

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Application

2-Bromo-2-chloro-1,1,1-trifluoroethane, or halothane, has been used in a study that combined molecular simulations with free energy simulations to study solvation of halothane in polarizable water and methanol. Halothane has also been used in a study to investigate the interaction of anesthetics with the Rho GTPase regulator Rho GDP dissociation inhibitor.

Packaging

125, 250 mL in glass bottle

Biochem/physiol Actions

Inhalation anesthetic. In an effect believed to be independent of anesthesia, halothane inhibits synthesis of 5-hydroxytryptamine in brain tissue, probably at the tryptophan hydroxylase step.

Signal Word

Danger

Hazard Statements

Target Organs

Respiratory system

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

UN 3334

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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