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B4636

Boc-Leu-Ser-Thr-Arg-7-amido-4-methylcoumarin

protein C substrate, ≥98% (HPLC), powder

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About This Item

Empirical Formula (Hill Notation):
C34H52N8O10
CAS Number:
73554-93-5
Molecular Weight:
732.82
MDL number:
MFCD00080226
UNSPSC Code:
12352204
PubChem Substance ID:
24891793
NACRES:
NA.32

Key Documents

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Product Name

Boc-Leu-Ser-Thr-Arg-7-amido-4-methylcoumarin, protein C substrate

Quality Level

200

assay

≥98% (HPLC)

form

powder

solubility

ethanol: 2 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

CC(C)CC(NC(=O)OC(C)(C)C)C(=O)NC(CO)C(=O)NC(C(C)O)C(=O)NC(CCCNC(N)=N)C(=O)Nc1ccc2C(C)=CC(=O)Oc2c1

InChI

1S/C34H52N8O10/c1-17(2)13-23(41-33(50)52-34(5,6)7)29(47)40-24(16-43)30(48)42-27(19(4)44)31(49)39-22(9-8-12-37-32(35)36)28(46)38-20-10-11-21-18(3)14-26(45)51-25(21)15-20/h10-11,14-15,17,19,22-24,27,43-44H,8-9,12-13,16H2,1-7H3,(H,38,46)(H,39,49)(H,40,47)(H,41,50)(H,42,48)(H4,35,36,37)

InChI key

ZJNWKMRGENOMCV-UHFFFAOYSA-N

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1 of 4

This Item
A8171B9936S9761
Boc-Leu-Ser-Thr-Arg-7-amido-4-methylcoumarin protein C substrate

Sigma-Aldrich

B4636

Boc-Leu-Ser-Thr-Arg-7-amido-4-methylcoumarin

D-Ala-Leu-Lys-7-amido-4-methylcoumarin ≥95% (HPLC)

Sigma-Aldrich

A8171

D-Ala-Leu-Lys-7-amido-4-methylcoumarin

Boc-Ile-Glu-Gly-Arg-7-amido-4-methylcoumarin acetate salt ≥97% (HPLC)

Sigma-Aldrich

B9936

Boc-Ile-Glu-Gly-Arg-7-amido-4-methylcoumarin acetate salt

N-Succinyl-Ala-Ala-Pro-Phe-7-amido-4-methylcoumarin Leucine aminopeptidase substrate

Sigma-Aldrich

S9761

N-Succinyl-Ala-Ala-Pro-Phe-7-amido-4-methylcoumarin

assay

≥98% (HPLC)

assay

≥95% (HPLC)

assay

≥97% (HPLC)

assay

≥98% (HPLC)

solubility

ethanol: 2 mg/mL, clear, colorless

solubility

water: 1 mg/mL, clear, colorless

solubility

methanol: 2 mg/mL, clear, colorless

solubility

methanol: 50 mg/mL, clear, colorless

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

powder

form

powder

form

powder

form

powder

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

General description

A fluorogenic substrate for activated protein C.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
SLCN8793
SLCM8533
SLBZ6420
SLBX4758
SLBL6158V

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Brian T O'Neill et al.
The Journal of clinical investigation, 126(9), 3433-3446 (2016-08-16)
Diabetes strongly impacts protein metabolism, particularly in skeletal muscle. Insulin and IGF-1 enhance muscle protein synthesis through their receptors, but the relative roles of each in muscle proteostasis have not been fully elucidated. Using mice with muscle-specific deletion of the
H Sawada et al.
The Journal of experimental zoology, 254(1), 83-87 (1990-04-01)
Enzymatic properties of a protease involved in hatching of mouse embryos were examined. A trypsin-like protease, which most efficiently hydrolyzed t-butoxycarbonyl-Leu-Ser-Thr-Arg-4-methylcoumaryl-7-amide, was demonstrated in culture medium of mouse hatching embryos. The enzyme was strongly inhibited by diisopropyl fluorophosphate, phenylmethanesulfonyl fluoride
Y Ohno et al.
Journal of biochemistry, 90(5), 1387-1395 (1981-11-01)
Protein C is a precursor of plasma serine proteinases, and its active form inactivates specifically blood coagulation Factor V and Factor VIII. Since a specific and sensitive synthetic substrate for the activated protein C was not known, we studied its
Ming Li et al.
Ecotoxicology and environmental safety, 135, 24-31 (2016-09-28)
Avermectins (AVMs) are used worldwide in agriculture and veterinary medicine. Residues of avermectin drugs, causing toxicological effects on non-target organisms, have raised great concern. The aim of this study was to investigate the effects of AVM on the expression levels
M A Nurseitova et al.
Journal of dairy science, 102(9), 7723-7733 (2019-07-01)
Milk fat adulteration is a common issue in Central Asia. To assess the current situation in the commercial milk market, 17 milk samples were checked for fatty acid (FA) and sterol profiles to detect potential adulteration using multivariate analysis. Analysis
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