B4666

5-Bromo-4-chloro-3-indolyl α-D-N-acetylneuraminic acid sodium salt

Name: 5-Bromo-4-chloro-3-indolyl &#945;-<SC>D</SC>-N-acetylneuraminic acid sodium salt
Brand: SIGMA
Price: 308 USD
Availability: InStock

≥90%, powder

Synonym(s):

X-NeuNAc

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About This Item

Linear Formula:

C₁₉H₂₁BrClN₂O₉Na

CAS Number:

160369-85-7

Molecular Weight:

559.72

UNSPSC Code:

12352204

PubChem Substance ID:

24891798

NACRES:

NA.32

MDL number:

MFCD01310489

Key Documents

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Product Name

5-Bromo-4-chloro-3-indolyl α-D-N-acetylneuraminic acid sodium salt, ≥90%

SMILES string

[Na].CC(=O)NC1C(O)CC(OC1C(O)C(O)CO)(Oc2c[nH]c3ccc(Br)c(Cl)c23)C(O)=O

InChI

1S/C19H22BrClN2O9.Na.H/c1-7(25)23-15-10(26)4-19(18(29)30,32-17(15)16(28)11(27)6-24)31-12-5-22-9-3-2-8(20)14(21)13(9)12;;/h2-3,5,10-11,15-17,22,24,26-28H,4,6H2,1H3,(H,23,25)(H,29,30);;

InChI key

QOSVDASAURDXES-UHFFFAOYSA-N

assay

≥90%

form

powder

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

storage temp.

−20°C

Quality Level

200

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Show Differences

1 of 4

This Item	B5285	M8639	N1516
Sigma-Aldrich B4666 5-Bromo-4-chloro-3-indolyl α-D-N-acetylneuraminic acid sodium salt	Sigma-Aldrich B5285 5-Bromo-4-chloro-3-indolyl β-D-glucuronide sodium salt	Sigma-Aldrich M8639 2′-(4-Methylumbelliferyl)-α-D-N-acetylneuraminic acid sodium salt hydrate	Sigma-Aldrich N1516 2-O-(p-Nitrophenyl)-α-D-N-acetylneuraminic acid
assay ≥90%	assay ≥98%	assay ≥95% (HPLC)	assay ≥95%
solubility water: 50 mg/mL, clear, colorless to faintly yellow	solubility water: 50 mg/mL, clear, colorless	solubility water: 50 mg/mL, clear to slightly hazy, colorless to light yellow	solubility methanol: 25 mg/mL, clear, colorless to faintly yellow
Quality Level 200	Quality Level 200	Quality Level 300	Quality Level 200
form powder	form powder	form powder	form powder
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C

General description

Chromogenic substrate for neuraminidase

Application

5-Bromo-4-chloro-3-indolyl α-D-N-acetylneuraminic acid sodium salt has been used as a substrate for determining the neuraminidase enzymatic activity of

avian mycoplasma samples
Ornithobacterium rhinotracheale, a poultry pathogen
canine mycoplasma samples

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Versatile dual reporter gene systems for investigating stop codon readthrough in plants.

Nga T Lao et al.

PloS one, 4(10), e7354-e7354 (2009-10-10)

Translation is most often terminated when a ribosome encounters the first in-frame stop codon (UAA, UAG or UGA) in an mRNA. However, many viruses (and some cellular mRNAs) contain "stop" codons that cause a proportion of ribosomes to terminate and

A survey of avian Mycoplasma species for neuraminidase enzymatic activity

Bercic RL, et al.

Veterinary Microbiology, 130(3-4), 391-397 (2008)

Ornithobacterium rhinotracheale has neuraminidase activity causing desialylation of chicken and turkey serum and tracheal mucus glycoproteins

Kastelic S, et al.

Veterinary Microbiology, 162(2-4), 707-712 (2013)

Demonstration of neuraminidase activity in Mycoplasma neurolyticum and of neuraminidase proteins in three canine Mycoplasma species

Bercic RL, et al.

Veterinary Microbiology, 155(2-4), 425-429 (2012)

X-Neu5Ac: a novel substrate for chromogenic assay of neuraminidase activity in bacterial expression systems.

I Fujii et al.

Bioorganic & medicinal chemistry, 1(2), 147-149 (1993-08-01)

A chromogenic substrate 1, 5-bromo-4-chloroindol-3-yl 5-acetamido-3,5-dideoxy-alpha-D-glycero-D-galacto-2-nonulopyranosidon ic acid (X-Neu5Ac), has been synthesized to facilitate the screening of bacterial colonies or plaques for the detection of either natural or mutant neuraminidase activity. Substrate 1 was hydrolyzed by neuraminidase isolated from Clostridium

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5-Bromo-4-chloro-3-indolyl α-D-N-acetylneuraminic acid sodium salt