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Bleomycin sulfate from Streptomyces verticillus

crystalline, 1.5-2.0 U/mg

Bleo, Blenoxane, Blexane
CAS Number:
EC Number:
MDL number:
PubChem Substance ID:

Quality Level



specific activity

1.5-2.0 U/mg




H2O: 20 mg/mL

cation traces

Cu: ≤0.10%

antibiotic activity spectrum


Mode of action

DNA synthesis | interferes

storage temp.


SMILES string




InChI key


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General description

Bleomycin Sulfate is an antineoplastic antibiotic isolated from Streptomyces verticillus. It is recommended for use as a cell culture agent at 10-100 μg/mL.
Chemical structure: glycopeptide


Bleomycin sulfate from Streptomyces verticillus has been used:
  • to study the impact of telomere shortening in lung fibrosis
  • to induce lung injury and study its effect on CEACAM6 expression
  • as a DNA-alkylating agent to induce lung injury
  • study its effect on CEACAM6 expression
  • to cause lung injury
  • subsequent fibrosis in animals

Bleomycin Sulfate is an atineoplastic antibiotic isolated from Streptomyces verticillus. It is recommended for use as a cell culture agent at 10-100 μg/mL.


15 units in serum bottle

Biochem/physiol Actions

Bleomycin sulfate binds to DNA, causes ssDNA scission at specific base sequences and inhibits DNA synthesis. This inhibitory action requires bleomycin to bind oxygen and a metal ion. It can also cleave RNA, to a lesser degree but more selectively. It acts as an inducer and regulator of apoptosis and inhibits tumor angiogenesis.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at


This product is a mixture of glycopeptides antibiotics containing Bleomycin A2 (70%) and B2(30%). Bleomycins differ from each other in the terminal amine and show varying biological activity.


This product should be stored at 2-8°C.

Preparation Note

The product is soluble in water in water at 20 mg/mL and is active for several days. A solution of 2 units/mL in 0.1 M neutral potassium phosphate should be used within 14 days. A solution is active for three months at 3 units/mL in normal saline.

Other Notes

Keep container tightly closed in a dry and well-ventilated place, strongly hygroscopic


Health hazard

Signal Word


Hazard Statements

Hazard Classifications

Carc. 2 - Muta. 1B - Repr. 2

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects



Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

Product Information Sheet

More Documents

Quotes and Ordering

Expression of human carcinoembryonic antigen-related cell adhesion molecule 6 and alveolar progenitor cells in normal and injured lungs of transgenic mice
Lin S, et al.
Physiological Reports, 3(12), e12657-e12657 (2015)
Loss of CDKN2B promotes fibrosis via increased fibroblast differentiation rather than proliferation
Scruggs AM, et al.
American Journal of Respiratory Cell and Molecular Biology, 59(2), 200-214 (2018)
Telomere shortening activates TGF-betaSmads signaling in lungs and enhances both lipopolysaccharide and bleomycin-induced pulmonary fibrosis
Liu YY, et al.
Acta Pharmacologica Sinica, 39(11), 1735-1735 (2018)
Carcinogenicity of bleomycin sulfate and peplomycin sulfate after repeated subcutaneous application to rats
Habs M and Schmahl D
Oncology, 41(2), 114-119 (1984)
Assembly of the Elongin A ubiquitin ligase is regulated by genotoxic and other stresses
Weems JC, et al.
The Journal of Biological Chemistry, 290(24), 15030-15041 (2015)


DNA Damage and Repair

DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.

Related Content

Discover Bioactive Small Molecules for Apoptosis

Apoptosis, or programmed cell death (PCD), is a selective process for the removal of unnecessary, infected or transformed cells in various biological systems. As it plays a role in the homeostasis of multicellular organisms, apoptosis is tightly regulated through two principal pathways by a number of regulatory and effector molecules.

Discover Bioactive Small Molecules for Cell Cycle Research

n proliferating cells, the cell cycle consists of four phases. Gap 1 (G1) is the interval between mitosis and DNA replication that is characterized by cell growth. Replication of DNA occurs during the synthesis (S) phase, which is followed by a second gap phase (G2) during which growth and preparation for cell division occurs. Together, these three stages comprise the interphase phase of the cell cycle. Interphase is followed by the mitotic (M) phase.

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