B5556

Bay 11-7082

Name: Bay 11-7082
Brand: SIGMA
Price: 141 USD
Availability: InStock

≥98% (HPLC), powder, NF-kB/TNF-α inhibitor

Synonym(s):

(E)-3-(4-Methylphenylsulfonyl)-2-propenenitrile

Slide 1 of 1

Select a Size

10 MG

$141.00

Available to ship TODAYDetails

One Time Order

Request a Bulk Order

Subscriptions are currently unavailable.

About This Item

Empirical Formula (Hill Notation):

C₁₀H₉NO₂S

CAS Number:

19542-67-7

Molecular Weight:

207.25

UNSPSC Code:

12352200

PubChem Substance ID:

24891842

NACRES:

NA.77

MDL number:

MFCD00712162

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Key Documents

View All Documentation

Product Name

Bay 11-7082, ≥98% (HPLC), powder

SMILES string

Cc1ccc(cc1)S(=O)(=O)\C=C\C#N

InChI key

DOEWDSDBFRHVAP-KRXBUXKQSA-N

InChI

1S/C10H9NO2S/c1-9-3-5-10(6-4-9)14(12,13)8-2-7-11/h2-6,8H,1H3/b8-2+

assay

≥98% (HPLC)

form

powder

color

white

solubility

DMSO: >20 mg/mL
H₂O: insoluble

Quality Level

100

Related Categories

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item	B5681	SML2817	SML0607
Sigma-Aldrich B5556 Bay 11-7082	Sigma-Aldrich B5681 Bay 11-7085	Sigma-Aldrich SML2817 BAY-1797	Sigma-Aldrich SML0607 Ceranib-2
form powder	form solid	form powder	form powder
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
solubility DMSO: >20 mg/mL, H₂O: insoluble	solubility DMSO: soluble >25 mg/mL, H₂O: insoluble	solubility DMSO: 2 mg/mL, clear	solubility DMSO: 20 mg/mL, clear
color white	color white	color white to beige	color white to beige

Application

Bay 11-7082 has been used as:

a nuclear factor-kappa B (NF-kB) inhibitor to verify the action of the NF-kB signaling pathway in the production of interleukin (IL)-8[1]
a nuclear factor-kappa B (NF-kB) inhibitor to study the role of NF-kB activation in Mycoplasma hyorhinis -induced epithelial-mesenchymal transition (EMT) and cell migration[2]
a nod-like receptor family pyrin domain containing 3 (NLRP3) selective inhibitor to examine its effects on liver inflammation in mice after hematopoietic stem cell transplantation[3]

Biochem/physiol Actions

Bay 11-7082 acts as a selective inhibitor for nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome pathway.[4] In addition, to the inhibition of nuclear factor-kappa B (NF-kB), Bay 11-7082 also triggers apoptosis in anucleated erythrocytes[5], human T-cell leukemia virus type I (HTLV-I)-infected T-cell lines and primary adult T-cell leukemia cells.[6]

Bay 11-7082 is an inhibitor of cytokine-induced IκB-α phosphorylation.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

0000517953

0000449713

0000283248

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Bay 11-7082 inhibits transcription factor NF-kappaB and induces apoptosis of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cells

Mori N, et al.

Blood, 100(5), 1828-1834 (2002)

Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome

Juliana C, et al.

The Journal of Biological Chemistry, 285(13), 9792-9802 (2010)

Lipopolysaccharide-induced α-catenin downregulation enhances the motility of human colorectal cancer cells in an NF-κB signaling-dependent manner.

Guoping Cheng et al.

OncoTargets and therapy, 9, 7563-7571 (2016-12-23)

α-Catenin is an important molecule involved in the maintenance of cell-cell adhesion and a prognostic marker in cancer since its expression is essential for preventing cancer metastasis. However, the mechanism that leads to the downregulation of α-catenin in cancer progression

Mycoplasma hyorhinis induces epithelial-mesenchymal transition in gastric cancer cell MGC803 via TLR4-NF-kappaB signaling

Duan H, et al.

Cancer Letters, 354(2), 447-454 (2014)

The NFkB pathway inhibitors Bay 11-7082 and parthenolide induce programmed cell death in anucleated Erythrocytes

Ghashghaeinia, et al.

Cellular Physiology and Biochemistry, 27(1), 45-54 (2011)

View All Related Papers

Articles

Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service

Bay 11-7082