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B5681

Bay 11-7085

≥98% (HPLC), solid

Synonym(s):

(E)-3-(4-t-Butylphenylsulfonyl)-2-propenenitrile

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10 MG

$189.00

$189.00

Estimated to ship onFebruary 26, 2026Details

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About This Item

Empirical Formula (Hill Notation):
C13H15NO2S
CAS Number:
196309-76-9
Molecular Weight:
249.33
NACRES:
NA.77
PubChem Substance ID:
24278273
UNSPSC Code:
12352200
MDL number:
MFCD01862602

Key Documents

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InChI key

VHKZGNPOHPFPER-ONNFQVAWSA-N

SMILES string

CC(C)(C)c1ccc(cc1)S(=O)(=O)\C=C\C#N

InChI

1S/C13H15NO2S/c1-13(2,3)11-5-7-12(8-6-11)17(15,16)10-4-9-14/h4-8,10H,1-3H3/b10-4+

assay

≥98% (HPLC)

form

solid

color

white

solubility

DMSO: soluble >25 mg/mL, H2O: insoluble

Quality Level

100

Gene Information

human ... NFKB1(4790)

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This Item
B5556S5192196870
Bay 11-7085 ≥98% (HPLC), solid

Sigma-Aldrich

B5681

Bay 11-7085

Bay 11-7082 ≥98% (HPLC), powder

Sigma-Aldrich

B5556

Bay 11-7082

SB 222200 ≥98% (HPLC), solid

Sigma-Aldrich

S5192

SB 222200

BAY 11-7082 The BAY 11-7082, also referenced under CAS 19542-67-7, controls the biological activity of TNF-α. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

Sigma-Aldrich

196870

BAY 11-7082

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

solid

form

powder

form

solid

form

solid

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

solubility

DMSO: soluble >25 mg/mL, H2O: insoluble

solubility

DMSO: >20 mg/mL, H2O: insoluble

solubility

DMSO: soluble ~28 mg/mL, H2O: insoluble

solubility

DMSO: 200 mg/mL

color

white

color

white

color

light yellow

color

off-white

Gene Information

human ... NFKB1(4790)

Gene Information

-

Gene Information

human ... TACR2(6865), TACR3(6870)

Gene Information

-

Application

Bay 11-7085 has been used as:
  • nuclear factor-κB inhibitor in Panc-1 cells[1], macrophages[2]
  • inhibitory κB kinase IKK inhibitor in human astrocytoma cells U87MGs[3]
  • phospho-p65 inhibitor human monocyte cell line THP-1[4]

Biochem/physiol Actions

Bay 11-7085 inactivates peroxisome proliferator-activated receptors γ (PPAR-γ) and increases the microtubule-associated proteins 1A/1B light chain 3B (LC3B), a marker of autophagy resulting in apoptosis in human synovial fibroblasts.[5] It promotes apoptosis in pancreatic carcinoma and may serve as radiotherapy-sensitizing drug.[6] BAY 11-7085 decreases B-cell lymphoma 2 (Bcl-2) by inhibiting pI-κBα (inhibitor of nuclear factor κ B kinase subunit α[7]
Inhibits NF-κB activated expression of ICAM-1, VCAM-1, E-selectin, IL-6 and IL-8.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000258882
0000258882
0000137473
0000103131
0000033979

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Maturational differences in lung NF-kappaB activation and their role in tolerance to hyperoxia
Yang G, et al.
The Journal of Clinical Investigation, 114(5), 669-678 (2004)
Impact of Bay 11-7085 on radiosensitivity of pancreatic cancer cell line Sw1990
Shu C, et al.
International Journal of Clinical and Experimental Medicine, 9(6), 9322-9326 (2016)
BAY 11-7085 induces glucocorticoid receptor activation and autophagy that collaborate with apoptosis to induce human synovial fibroblast cell death
Relic B, et al.
Oncotarget, 7(17), 23370-23370 (2016)
Loss of nucleobindin-2 causes insulin resistance in obesity without impacting satiety or adiposity
Ravussin A, et al.
Testing, 24(5), 1085-1092 (2018)
Qin Yan et al.
PLoS pathogens, 10(6), e1004149-e1004149 (2014-06-06)
Using A/J mice, which are susceptible to Staphylococcus aureus, we sought to identify genetic determinants of susceptibility to S. aureus, and evaluate their function with regard to S. aureus infection. One QTL region on chromosome 11 containing 422 genes was
View All Related Papers

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