B7273

Bezafibrate

≥98%, solid

• Synonym(s): 2-[4-[2-(4-Chlorobenzamido)ethyl]phenoxy]-2-methylpropanoic acid
• Empirical Formula (Hill Notation): C₁₉H₂₀ClNO₄
• CAS Number: 41859-67-0
• Molecular Weight: 361.82
• EC Number: 255-567-9
• MDL number: MFCD00078970
• UNSPSC Code: 12352200
• PubChem Substance ID: 24891983
• NACRES: NA.77

Properties

• assay: ≥98%
• form: solid
• solubility: DMF: soluble; deionized water: insoluble; methanol: soluble
• originator: Roche
• SMILES string: CC(C)(Oc1ccc(CCNC(=O)c2ccc(Cl)cc2)cc1)C(O)=O
• InChI: 1S/C19H20ClNO4/c1-19(2,18(23)24)25-16-9-3-13(4-10-16)11-12-21-17(22)14-5-7-15(20)8-6-14/h3-10H,11-12H2,1-2H3,(H,21,22)(H,23,24)
• InChI key: IIBYAHWJQTYFKB-UHFFFAOYSA-N
• Gene Information: human ... HBA2(3040), PPARA(5465), PPARD(5467), PPARG(5468) ; mouse ... Ppara(19013), Ppard(19015), Pparg(19016)

Description

Application

Bezafibrate has been used:

• a supplement in the standard diet (SD) for mice to study its effect on diabetes[1][2]
• to evaluate its effect on hepatitis C virus (HCV) assembly and secretion[3]
• to evaluate its effect on gonadal steroidogenesis and spermatogenesis of zebrafish and also used as standard for HPLC[4]

Biochem/physiol Actions

Bezafibrate has the ability to repress HCV assembly and secretion. It is used to treat dyslipidemia.[3]

Bezafibrate is a peroxisome proliferator-activated receptor agonist for PPARα, PPARδ, and PPARγ. Lipoprotein lipase (LPL) activator.

The peroxisome proliferator-activated receptor (PPAR) is a member of the steroid nuclear receptor superfamily. Bezafibrate is a peroxisome proliferator-activated receptor agonist for PPARα, PPARδ, and PPARγ. Lipoprotein lipase (LPL) activator.
PPARgamma agonists, including Bezafibrate, have beneficial effects in the suppression of the inflammatory response during RSV infection and therefore might have clinical efficacy in the course of severe RSV-infection.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves