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Bezafibrate

Name: Bezafibrate
Brand: SIGMA
Price: 48.8 USD

≥98%, peroxisome proliferator-activated receptor agonist, solid

Synonym(s):

2-[4-[2-(4-Chlorobenzamido)ethyl]phenoxy]-2-methylpropanoic acid

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Pack Size	Availability	Price
1 g	Check Cart for Availability	$48.80
5 g	Check Cart for Availability	$162.00
25 g	Check Cart for Availability	$520.00 $442.00

About This Item

Empirical Formula (Hill Notation):

C₁₉H₂₀ClNO₄

CAS Number:

41859-67-0

Molecular Weight:

361.82

NACRES:

NA.77

PubChem Substance ID:

24891983

UNSPSC Code:

12352200

EC Number:

255-567-9

MDL number:

MFCD00078970

Assay:

≥98%

Form:

solid

Quality level:

200

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Properties

Product Name

Bezafibrate, ≥98%, solid

Quality Level

200

assay

≥98%

form

solid

solubility

DMF: soluble, deionized water: insoluble, methanol: soluble

originator

Roche

SMILES string

CC(C)(Oc1ccc(CCNC(=O)c2ccc(Cl)cc2)cc1)C(O)=O

InChI

1S/C19H20ClNO4/c1-19(2,18(23)24)25-16-9-3-13(4-10-16)11-12-21-17(22)14-5-7-15(20)8-6-14/h3-10H,11-12H2,1-2H3,(H,21,22)(H,23,24)

InChI key

IIBYAHWJQTYFKB-UHFFFAOYSA-N

Gene Information

human ... HBA2(3040), PPARA(5465), PPARD(5467), PPARG(5468)
mouse ... Ppara(19013), Ppard(19015), Pparg(19016)

Description

Application

Bezafibrate has been used:

a supplement in the standard diet (SD) for mice to study its effect on diabetes
to evaluate its effect on hepatitis C virus (HCV) assembly and secretion[1]
to evaluate its effect on gonadal steroidogenesis and spermatogenesis of zebrafish and also used as standard for HPLC

Biochem/physiol Actions

Bezafibrate has the ability to repress HCV assembly and secretion. It is used to treat dyslipidemia.[1]

Bezafibrate is a peroxisome proliferator-activated receptor agonist for PPARα, PPARδ, and PPARγ. Lipoprotein lipase (LPL) activator.

The peroxisome proliferator-activated receptor (PPAR) is a member of the steroid nuclear receptor superfamily. Bezafibrate is a peroxisome proliferator-activated receptor agonist for PPARα, PPARδ, and PPARγ. Lipoprotein lipase (LPL) activator.
PPARgamma agonists, including Bezafibrate, have beneficial effects in the suppression of the inflammatory response during RSV infection and therefore might have clinical efficacy in the course of severe RSV-infection.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Show Differences

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This Item	F6020	E8280	B1115000
Sigma-Aldrich B7273 Bezafibrate	Sigma-Aldrich F6020 Fenofibrate	Sigma-Aldrich E8280 Exo 1	B1115000 Bezafibrate
assay ≥98%	assay ≥99%	assay ≥98% (HPLC)	assay -
form solid	form powder	form solid	form -
Quality Level 200	Quality Level 100	Quality Level 100	Quality Level -
solubility DMF: soluble, methanol: soluble, deionized water: insoluble	solubility -	solubility DMSO: soluble 19 mg/mL	solubility -
Gene Information human ... HBA2(3040), PPARA(5465), PPARD(5467), PPARG(5468) mouse ... Ppara(19013), Ppard(19015), Pparg(19016)	Gene Information human ... PPARA(5465)	Gene Information -	Gene Information human ... PPARA(5465), PPARD(5467), PPARG(5468)
originator Roche	originator Abbott	originator -	originator -

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pictograms

GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Articles

Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

Bezafibrate ameliorates diabetes via reduced steatosis and improved hepatic insulin sensitivity in diabetic TallyHo mice

Franko A, et al.

Molecular Metabolism, 6(3), 256-266 (2017)

Bezafibrate for X-linked adrenoleukodystrophy.

Marc Engelen et al.

PloS one, 7(7), e41013-e41013 (2012-08-23)

X-linked adrenoleukodystrophy (X-ALD) is caused by mutations in the ABCD1 gene and is characterized by impaired beta-oxidation of very-long-chain fatty acids (VLCFA) and subsequent VLCFA accumulation in tissues. In adulthood X-ALD most commonly manifests as a gradually progressive myelopathy, (adrenomyeloneuropathy;

Bezafibrate improves insulin sensitivity and metabolic flexibility in STZ-induced diabetic mice