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MilliporeSigma

B7431

Bryostatin 1

≥99%, Protein kinase C activator, solid

Synonym(s):

NSC 339555

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10 μG

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About This Item

Empirical Formula (Hill Notation):
C47H68O17
CAS Number:
83314-01-6
Molecular Weight:
905.03
MDL number:
MFCD00893832
UNSPSC Code:
12352200
PubChem Substance ID:
24891991
NACRES:
NA.77

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Product Name

Bryostatin 1, ≥99%, solid

Quality Level

100

assay

≥99%

form

solid

color

white

solubility

DMSO: soluble
ethanol: soluble

storage temp.

−20°C

SMILES string

[H]\C(C(=O)OC)=C1/C[C@@]2([H])C[C@]3(O)O[C@]([H])(C[C@@H](O)CC(=O)O[C@H](C[C@]4([H])C\C(=C(\[H])C(=O)OC)[C@H](OC(=O)\C=C\C=C\CCC)[C@@](O)(O4)C(C)(C)\C=C\[C@@]([H])(C1)O2)[C@@H](C)O)C[C@H](OC(C)=O)C3(C)C

InChI

1S/C47H68O17/c1-10-11-12-13-14-15-39(51)62-43-31(22-41(53)58-9)21-34-25-37(28(2)48)61-42(54)24-32(50)23-35-26-38(59-29(3)49)45(6,7)46(55,63-35)27-36-19-30(20-40(52)57-8)18-33(60-36)16-17-44(4,5)47(43,56)64-34/h12-17,20,22,28,32-38,43,48,50,55-56H,10-11,18-19,21,23-27H2,1-9H3/b13-12+,15-14+,17-16+,30-20+,31-22+/t28-,32-,33+,34+,35-,36+,37-,38+,43+,46+,47-/m1/s1

InChI key

MJQUEDHRCUIRLF-TVIXENOKSA-N

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Show Differences

1 of 4

This Item
D7408D1068N9162
Bryostatin 1 ≥99%, solid

Sigma-Aldrich

B7431

Bryostatin 1

2′,5′-Dideoxyadenosine ≥95% (HPLC), solid

Sigma-Aldrich

D7408

2′,5′-Dideoxyadenosine

DCB ≥98% (HPLC), solid

Sigma-Aldrich

D1068

DCB

Neocarzinostatin from Streptomyces carzinostaticus ≥90% (SDS-PAGE), ~0.5 mg/mL

Sigma-Aldrich

N9162

Neocarzinostatin from Streptomyces carzinostaticus

form

solid

form

solid

form

solid

form

solution

assay

≥99%

assay

≥95% (HPLC)

assay

≥98% (HPLC)

assay

≥90% (SDS-PAGE)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

200

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: soluble, ethanol: soluble

solubility

DMSO: soluble

solubility

DMSO: ~6.8 mg/mL, H2O: insoluble

solubility

-

color

white

color

white

color

yellow

color

-

Application

Bryostatin 1 has been used to study its effects on spontaneous Crohn′s disease (CD) like colitis in mice.[1] It has also been used to study its effects as an anthelmintic drug on adult Syphacia muris infection in rats.[2]

Biochem/physiol Actions

Bryostatin 1 (Bry1) is a macrocyclic lactone.[3] This synaptogenic compound[4] is obtained from the marine bryozoan Bugula neritina.[1] Bry1 is capable of reversing synaptic loss. It can enable synaptic maturation in animal models with several neurological disorders.[3] It possesses antidepressant activity, when administered intracebroventricularly.[4] Bry1 is known to participate in protecting cell tight junctions (TJs), anti-inflammatory functions and immune regulation.[1]
Macrolactone isolated from the marine bryozoan Bugula neritina that initially activates and subsequently down-regulates protein kinase C (PKC). More potent than phorbol myristate acetate for translocating PKCδ and ε.

Other Notes

Binds to glass and plastic in aqueous solutions

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
MKCZ6729
MKCZ6728
MKCX7100
MKCV6265
MKCW8251

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Jarin Hongpaisan et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(2), 630-643 (2011-01-14)
Among the pathologic hallmarks of Alzheimer's disease (AD) neurodegeneration, only synaptic loss in the brains of AD patients closely correlates with the degree of dementia in vivo. Here, we describe a molecular basis for this AD loss of synapses: pathological
Maria Eugenia Ariza et al.
The Journal of biological chemistry, 286(1), 24-34 (2010-11-03)
Bryostatin-1 (Bryo-1), a natural macrocyclic lactone, is clinically used as an anti-cancer agent. In this study, we demonstrate for the first time that Bryo-1 acts as a Toll-like receptor 4 (TLR4) ligand. Interestingly, activation of bone marrow-derived dendritic cells (in
Maciej Kmieciak et al.
Journal of visualized experiments : JoVE, (47)(47), doi:10-doi:10 (2011-02-10)
It was reported that breast cancer patients have pre-existing immune responses against their tumors(1,2). However, such immune responses fail to provide complete protection against the development or recurrence of breast cancer. To overcome this problem by increasing the frequency of
Moisés Pérez et al.
Current HIV research, 8(6), 418-429 (2010-07-20)
The persistence of latent HIV-infected cellular reservoirs represents the major hurdle to virus eradication on patients treated with HAART. It has been suggested that successful depletion of such latent reservoirs will require a combination of therapeutic agents that can specifically
B Douglas Smith et al.
Leukemia research, 35(1), 87-94 (2010-07-06)
Pharmacologic differentiating agents have had relatively limited clinical success outside of the use of ATRA in acute promyelocytic leukemia and DNA methyltransferase inhibitors in myelodysplastic syndromes. The differentiating effects of such agents can be enhanced in combination with lineage-specific growth
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