B8299

N-Butyldeoxynojirimycin

film (dried in situ)

• Synonym(s): Miglustat, NB-DNJ
• Empirical Formula (Hill Notation): C₁₀H₂₁NO₄
• CAS Number: 72599-27-0
• Molecular Weight: 219.28
• MDL number: MFCD00272581
• PubChem Substance ID: 24892070
• NACRES: NA.32

Properties

• Assay: ≥98% (TLC)
• Quality Level: 200
• form: film (dried in situ)
• solubility: water: 9.80-10.20 mg/mL, clear, colorless
• storage temp.: 2-8°C
• SMILES string: CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
• InChI: 1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1
• InChI key: UQRORFVVSGFNRO-UTINFBMNSA-N
• Gene Information: human ... UGCG(7357)

Description

General description

N-Butyldeoxynojirimycin is an alkylated product of imino sugar deoxynojirimycin.

Application

N-Butyldeoxynojirimycin has been used:

• in the inhibition of glycolipid synthesis in neuroblastoma cells
• in the inhibition the ceramide-specific glycosyltransferase in hepatocytes
• in the inhibition of β-glucosidase (GBA2) using fluorescence- activity assay in human embryonic kidney (HEK293) cells.

Biochem/physiol Actions

N-Butyldeoxynojirimycin is an inhibitor of glucosyltransferase and α-glucosidases. N-Butyldeoxynojirimycin, also known as misglustat, reduces glycolipid levels by substrate reduction therapy (SRT) and is effectively used for the treatment of glycosphingolipid lysosomal storage disorder, Gaucher disease.

α-glucosidase Inhibitor

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves