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B9385

Boc-Val-Pro-Arg-7-amido-4-methylcoumarin hydrochloride

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5 MG

$175.00

$175.00

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About This Item

Empirical Formula (Hill Notation):
C31H45N7O7
CAS Number:
70375-24-5
Molecular Weight:
627.73
MDL number:
MFCD00058181
UNSPSC Code:
12352204
PubChem Substance ID:
24892134
NACRES:
NA.32

Key Documents

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assay

≥98% (TLC)

Quality Level

200

form

powder

solubility

water: 20 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

Cl.CC(C)C(NC(=O)OC(C)(C)C)C(=O)N1CCCC1C(=O)NC(CCCNC(N)=N)C(=O)Nc2ccc3C(C)=CC(=O)Oc3c2

InChI

1S/C31H45N7O7.ClH/c1-17(2)25(37-30(43)45-31(4,5)6)28(42)38-14-8-10-22(38)27(41)36-21(9-7-13-34-29(32)33)26(40)35-19-11-12-20-18(3)15-24(39)44-23(20)16-19;/h11-12,15-17,21-22,25H,7-10,13-14H2,1-6H3,(H,35,40)(H,36,41)(H,37,43)(H4,32,33,34);1H

Inchi Key

ROQGJTZGLVLVIN-UHFFFAOYSA-N

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This Item
B4153B4636B9936
Boc-Val-Pro-Arg-7-amido-4-methylcoumarin hydrochloride

Sigma-Aldrich

B9385

Boc-Val-Pro-Arg-7-amido-4-methylcoumarin hydrochloride

Boc-Gln-Ala-Arg-7-amido-4-methylcoumarin hydrochloride ~95%

Sigma-Aldrich

B4153

Boc-Gln-Ala-Arg-7-amido-4-methylcoumarin hydrochloride

Boc-Leu-Ser-Thr-Arg-7-amido-4-methylcoumarin protein C substrate

Sigma-Aldrich

B4636

Boc-Leu-Ser-Thr-Arg-7-amido-4-methylcoumarin

Boc-Ile-Glu-Gly-Arg-7-amido-4-methylcoumarin acetate salt ≥97% (HPLC)

Sigma-Aldrich

B9936

Boc-Ile-Glu-Gly-Arg-7-amido-4-methylcoumarin acetate salt

assay

≥98% (TLC)

assay

~95%

assay

≥98% (HPLC)

assay

≥97% (HPLC)

solubility

water: 20 mg/mL, clear, colorless

solubility

methanol: 50 mg/mL, clear, colorless

solubility

ethanol: 2 mg/mL, clear, colorless

solubility

methanol: 2 mg/mL, clear, colorless

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

powder

form

powder

form

powder

form

powder

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

General description

A fluorogenic substrate for thrombin.
Boc-Val-Pro-Arg-AMC serves as a synthetic substrate for human kallikrein 8.[1]

Application

Boc-Val-Pro-Arg-7-amido-4-methylcoumarin hydrochloride has been used:
  • as a fluorogenic substrate for thrombin in inhibitory assay with salivary protein cE5[2]
  • as a fluorogenic substrate for thrombin in inhibitory assay with recombinant E. nipponicum serpin[3]
  • as a substrate in proteinase assay with hemolymph protein[4]

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCM4330
BCCL2939
BCCK3625
BCCH2497
BCCG1065

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Tadaaki Kishi et al.
Biological chemistry, 387(6), 723-731 (2006-06-28)
Human kallikrein 8 (hK8), whose gene was originally cloned as the human ortholog of a mouse brain protease, is known to be associated with diseases such as ovarian cancer and Alzheimer's disease. Recombinant human pro-kallikrein 8 was activated with lysyl
Luciano Pirone et al.
The Journal of biological chemistry, 292(30), 12632-12642 (2017-06-09)
Saliva of blood-feeding arthropods carries several antihemostatic compounds whose physiological role is to facilitate successful acquisition of blood. The identification of novel natural anticoagulants and the understanding of their mechanism of action may offer opportunities for designing new antithrombotics disrupting
Jantiwan Sutthangkul et al.
The Journal of biological chemistry, 290(10), 6470-6481 (2015-01-13)
The melanization cascade, activated by the prophenoloxidase (proPO) system, plays a key role in the production of cytotoxic intermediates, as well as melanin products for microbial sequestration in invertebrates. Here, we show that the proPO system is an important component
Pavel Roudnický et al.
Parasite (Paris, France), 25, 61-61 (2018-12-06)
Serpins are a superfamily of serine peptidase inhibitors that participate in the regulation of many physiological and cell peptidase-mediated processes in all organisms (e.g. in blood clotting, complement activation, fibrinolysis, inflammation, and programmed cell death). It was postulated that in
T Morita et al.
Journal of biochemistry, 82(5), 1495-1498 (1977-11-01)
Twenty peptide-4-methylcoumarin amides (MCA) were newly synthesized and tested as possible substrates for alpha-thrombin, factor Xa, kallikreins, urokinase, and plasmin. These fluorogenic peptides contained arginine-MCA as the carboxyl-terminus. Release of 7-amino-4-methylcoumarin was determined fluorometrically. Of these peptides, the following were
View All Related Papers

Protocols

Thrombin from Bovine Plasma

Thrombin is an endolytic serine protease that selectively cleaves the Arg–Gly bonds of fibrinogen to form fibrin and release fibrinopeptides A and B.

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