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B9928

Sigma-Aldrich

Anti-Bone Morphogenetic Protein Receptor 2 antibody produced in goat

affinity isolated antibody, lyophilized powder

Synonym(s):
Anti-BMP R2
MDL number:
Pricing and availability is not currently available.

biological source

goat

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

human

application(s)

indirect ELISA: 0.5-1.0 μg/mL
western blot: 0.1-0.2 μg/mL

conjugate

unconjugated

UniProt accession no.

storage temp.

−20°C

Gene Information

human ... BMPR2(659)

General description

Bone morphogenetic proteins (BMPs) are the members of the TGF-β superfamily and are identified as the critical factors for formation of bone and cartilage, hematopoietic cell formation and mesoderm patterning. Apart from this BMPs have immune regulatory functions. The cellular effects of BMPs are mediated by a heteromeric complex composed of type I and type II receptors. Bone Morphogenetic Protein Receptor 2 (BMP R2) is a 70-80kD protein that belongs to serine/threonine kinases family. BMPs bind to BMP R2 and then recruits the transducing type I receptor which in turn activate the Smad protein signaling pathway. Anti-Bone Morphogenetic Protein Receptor 2 (BMP R2) antibody can be used in western blotting (working concentration:- 0.1-0.2 μg/mL). Goat anti-BMP R2 antibody reacts specifically with recombinant human BMP-R2. The antibody exhibits 10% (approx.) cross-reactivity with recombinant mouse BMP-RIB using reducing conditions and less than 1% cross-reactivity with recombinant mouse BMP-RIA and recombinant human BMP-RIA.

Specificity

By immunoblotting (reducing conditions), the antibody shows 10% cross-reactivity with recombinant mouse BMP RIB and <1% cross-reactivity with recombinant human BMP RIA and recombinant mouse BMP RIA.

Immunogen

recombinant human BMP R2 expressed in NSO cells.

Application

Anti-Bone Morphogenetic Protein Receptor 2 (BMP R2) antibody may be used in indirect ELISA at a working antibody concentration of 0.5-1.0 μg/ml.

Physical form

Lyophilized from solution in phosphate buffered saline containing 5% trehalose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Certificate of Analysis
Certificate of Origin
TGF-beta receptor signaling.
R Derynck et al.
Biochimica et biophysica acta, 1333(2), F105-F150 (1997-12-12)
J Massagué et al.
Trends in cell biology, 4(5), 172-178 (1994-05-01)
In their search for regulators of animal growth and development, biologists have often come upon members of the transforming growth factor beta (TGF-beta) family and have realized that these are among the most versatile carriers of growth and differentiation signals....
P C Bessa et al.
Journal of tissue engineering and regenerative medicine, 2(1), 1-13 (2008-02-23)
Discovered in 1965, bone morphogenetic proteins (BMPs) are a group of cytokines from the transforming growth factor-beta (TGFbeta) superfamily with significant roles in bone and cartilage formation. BMPs are used as powerful osteoinductive components of diverse tissue-engineering products for the...
L Attisano et al.
Cell, 75(4), 671-680 (1993-11-19)
Transforming growth factor beta (TGF beta) and activin each bind to pairs of membrane proteins, known as receptor types I and II, that associate to form a signaling complex. We report that TSR-I and ActR-I, two human transmembrane serine/threonine kinases...
Kohei Miyazono et al.
Cytokine & growth factor reviews, 16(3), 251-263 (2005-05-06)
Bone morphogenetic proteins (BMPs), members of the transforming growth factor-beta (TGF-beta) superfamily, bind to two different serine/threonine kinase receptors, and mediate their signals through Smad-dependent and Smad-independent pathways. Receptor regulated-Smad (R-Smad) proteins specific for the BMP pathways interact with various...

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