TGF-beta receptor signaling.
R Derynck et al.
Biochimica et biophysica acta, 1333(2), F105-F150 (1997-12-12)
J Massagué et al.
Trends in cell biology, 4(5), 172-178 (1994-05-01)
In their search for regulators of animal growth and development, biologists have often come upon members of the transforming growth factor beta (TGF-beta) family and have realized that these are among the most versatile carriers of growth and differentiation signals....
P C Bessa et al.
Journal of tissue engineering and regenerative medicine, 2(1), 1-13 (2008-02-23)
Discovered in 1965, bone morphogenetic proteins (BMPs) are a group of cytokines from the transforming growth factor-beta (TGFbeta) superfamily with significant roles in bone and cartilage formation. BMPs are used as powerful osteoinductive components of diverse tissue-engineering products for the...
L Attisano et al.
Cell, 75(4), 671-680 (1993-11-19)
Transforming growth factor beta (TGF beta) and activin each bind to pairs of membrane proteins, known as receptor types I and II, that associate to form a signaling complex. We report that TSR-I and ActR-I, two human transmembrane serine/threonine kinases...
Kohei Miyazono et al.
Cytokine & growth factor reviews, 16(3), 251-263 (2005-05-06)
Bone morphogenetic proteins (BMPs), members of the transforming growth factor-beta (TGF-beta) superfamily, bind to two different serine/threonine kinase receptors, and mediate their signals through Smad-dependent and Smad-independent pathways. Receptor regulated-Smad (R-Smad) proteins specific for the BMP pathways interact with various...