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C0166

Sigma-Aldrich

Cys-Gly

≥85% (TLC)

Synonym(s):
L-cysteinyl-glycine
Empirical Formula (Hill Notation):
C5H10N2O3S
CAS Number:
Molecular Weight:
178.21
MDL number:
PubChem Substance ID:
NACRES:
NA.26

Quality Level

assay

≥85% (TLC)

form

solid

technique(s)

HPLC: suitable

storage temp.

−20°C

SMILES string

NC(CS)C(=O)NCC(O)=O

InChI

1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)

InChI key

ZUKPVRWZDMRIEO-UHFFFAOYSA-N

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General description

Cys-Gly, a dipeptide is a catabolic byproduct of glutathione. [1]

Application

Cys-Gly has been used for derivatization by p-hydroxymercury benzoate (PHMB) for calibration of reversed phase chromatography coupled on-line and sequentially with a UV−visible diode array detector (RPLC-DAD).[2]

Biochem/physiol Actions

Cys-Gly is a precursor for glutathione biosynthesis in the neurons.[3] It favors reactive oxygen species generation in the presence of transition metal ions. A normal level of cys-gly is essential for normal cellular function.[1]
L-Cysteine-L-Glycine (Cys-Gly) is used in studies on the homeostasis of glutathione. Cys-Gly is an important molecule for study in the areas of thiol homeostasis, oxidative stress and metals management.

Other Notes

Glutathione fragment
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. C0166.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

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Certificate of Origin

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