Skip to Content
MilliporeSigma
All Photos(2)

Documents

C0400

Sigma-Aldrich

Carmustine

≥98% (TLC), oily liquid to amorphous solid, DNA alkylating agent

Synonym(s):

1,3-Bis(2-chloroethyl)-1-nitrosourea, BCNU

Sign Into View Organizational & Contract Pricing


About This Item

Empirical Formula (Hill Notation):
C5H9Cl2N3O2
CAS Number:
Molecular Weight:
214.05
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

product name

Carmustine, ≥98%

Quality Level

assay

≥98%

form

(Oily liquid to amorphous solid)

mp

30 °C (lit.)

solubility

ethanol: 19.60-20.40 mg/mL, clear, pale yellow to yellow

originator

Bristol-Myers Squibb

storage temp.

−20°C

SMILES string

ClCCNC(=O)N(CCCl)N=O

InChI

1S/C5H9Cl2N3O2/c6-1-3-8-5(11)10(9-12)4-2-7/h1-4H2,(H,8,11)

InChI key

DLGOEMSEDOSKAD-UHFFFAOYSA-N

Gene Information

human ... GSR(2936)

Looking for similar products? Visit Product Comparison Guide

Related Categories

General description

Carmustine is a mustard gas related β-chloro-nitrosourea compound, which is used in chemotherapy. It inhibits DNA replication and DNA transcription.

Application

Carmustine has been used to select transduced cells expressing MGMTP140K, a foamy virus vector. It has also been used in fluorescence-activated cell sorting (FACS) assay, to test the response of cell lines to carmustine.

Biochem/physiol Actions

Carmustine is a DNA alkylating agent causing DNA interstrand crosslinks. Effective against glioma and other solid tumors.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Skull and crossbonesHealth hazard

signalword

Danger

Hazard Classifications

Acute Tox. 2 Oral - Carc. 1B - Repr. 1B

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Slide 1 of 9

1 of 9

Ezatiostat ≥98% (HPLC)

Sigma-Aldrich

SML1081

Ezatiostat

Angelicin

Sigma-Aldrich

A0956

Angelicin

Chlorambucil

Sigma-Aldrich

C0253

Chlorambucil

Melphalan powder

Sigma-Aldrich

M2011

Melphalan

O6-Benzylguanine ≥98% (TLC), solid

Sigma-Aldrich

B2292

O6-Benzylguanine

Sigma-Aldrich

Sigma-Aldrich

C2235

CB 1954

8-Methoxypsoralen analytical standard

Supelco

M3501

8-Methoxypsoralen

Mapping the human kinome in response to DNA damage
Owusu M, et al.
Testing, 26(3), 555-563 (2019)
Foamy viral vector integration sites in SCID-repopulating cells after MGMTP140K-mediated in vivo selection
Olszko ME, et al
Gene Therapy, 22(7), 591-591 (2015)
Ching-Hsiang Fan et al.
Biomaterials, 34(8), 2142-2155 (2012-12-19)
Current chemotherapeutic agents do not only kill tumor cells but also induce systemic toxicity that significantly limits their dosage. Focused ultrasound (FUS) in the presence of microbubbles (MBs) is capable of transient and local opening of the blood-brain barrier (BBB)
John Blazeck et al.
Biotechnology journal, 5(7), 647-659 (2010-02-13)
The advent of high throughput genome-scale bioinformatics has led to an exponential increase in available cellular system data. Systems metabolic engineering attempts to use data-driven approaches--based on the data collected with high throughput technologies--to identify gene targets and optimize phenotypical
W Stahl et al.
Chemical research in toxicology, 5(1), 106-109 (1992-01-01)
S-[(2-Chloroethyl)carbamoyl]glutathione (SCCG), a compound formed during the decomposition of BCNU in the presence of GSH, induces DNA damage in a human lymphoblastoid cell line. This GSH conjugate was shown by direct fast atom bombardment mass spectrometric analysis to transfer an

Articles

DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.

Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.

Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service