C0889

Sigma-Aldrich

Cytochalasin H from Phomopsis sp.

Empirical Formula (Hill Notation):
C30H39NO5
CAS Number:
Molecular Weight:
493.63
Beilstein/REAXYS Number:
1632647
MDL number:
PubChem Substance ID:
NACRES:
NA.77
Pricing and availability is not currently available.

Quality Level

storage temp.

2-8°C

SMILES string

C[C@H]1C\C=C\C2[C@H](O)C(=C)[C@@H](C)C3[C@H](Cc4ccccc4)NC(=O)[C@@]23C(OC(C)=O)\C=C\[C@](C)(O)C1

InChI

1S/C30H39NO5/c1-18-10-9-13-23-27(33)20(3)19(2)26-24(16-22-11-7-6-8-12-22)31-28(34)30(23,26)25(36-21(4)32)14-15-29(5,35)17-18/h6-9,11-15,18-19,23-27,33,35H,3,10,16-17H2,1-2,4-5H3,(H,31,34)/b13-9+,15-14+/t18-,19+,23?,24-,25+,26?,27+,29-,30+/m0/s1

InChI key

NAEWXXDGBKTIMN-QHDZSFFESA-N

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Packaging

5 mg in glass bottle

Biochem/physiol Actions

Cytochalasin reported to have CNS activity

Pictograms

Skull and crossbonesHealth hazard

Signal Word

Danger

Hazard Statements

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Hazard Codes

T+

Risk Statement

63-26/27/28

Safety Statement

28-36/37-45

RIDADR

UN 3462 6.1 / PGII

WGK Germany

WGK 3

Effect of cytochalasins B & H on isoelectric focusing of chick embryonic neural retina cells.
S Ghaskadbi et al.
Indian journal of experimental biology, 20(12), 869-871 (1982-12-01)
S Ghaskadbi et al.
Toxicology, 33(3-4), 323-330 (1984-12-01)
Effects of the mould metabolite, cytochalasin H (CH) were studied in chick embryos explanted at stages 4, 5 and 8 and cultured in vitro. Morphological and histological observations revealed that the major effects of CH are inhibition of primary morphogenesis...
Scott M Stoeger et al.
Cancer chemotherapy and pharmacology, 63(5), 807-818 (2008-07-29)
Previous studies have indicated that the ERK1/2 MAP kinase signaling pathway plays an important role not only in cell growth, cell cycle regulation, and differentiation, but also in determining the sensitivity of cells to anticancer agents as well. Furthermore, expression...
S Ghaskadbi et al.
Experimental cell biology, 50(3), 155-161 (1982-01-01)
Cytochalasin H (CH) has been shown to inhibit the reaggregation of dissociated cells of a fresh water sponge. The effect is dose-dependent and reversible. Even after 24 h of CH treatment, the cells show the formation of pseudopodia suggesting that...
P Natarajan et al.
Platelets, 11(8), 467-476 (2001-02-15)
Platelets contain a well-developed and dynamic cytoskeleton composed mainly of actin and actin-associated proteins. Upon platelet activation there is rapid polymerisation of actin and a marked reorganisation of the platelet cytoskeleton. Cytochalasins are agents that interfere with the polymerisation of...

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