C1013

Sigma-Aldrich

Carrageenan

suitable for gel preparation

Synonym(s):
Vegetable gelatin
CAS Number:
EC Number:
MDL number:
NACRES:
NA.25

biological source

algae (red)

Quality Level

description

Predominantly κ and lesser amounts of λ carrageenan

form

powder

suitability

suitable for gel preparation

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General description

Carrageenans are mucopolysaccharides from the cell walls of the red algae. They are anionic linear polymers composed of 1,3α-1,4β-galactans having one (κ-), two (ι-) or three (λ-) sulfates per disaccharide unit. In ionic solutions, κ- and ι-carrageenans self-associate into helical structures that form rigid or flexible gels, respectively. λ-carrageenans do not form helices and are non-gelling. Carrageenans are used commercially as thickeners and stabilizing agents.

Application

Carrageenans are used to suppress immune response in vivo and in vitro via mechanisms believed to involve selective cytopathic effect on macrophages. As ι-, κ-, and λ- carrageenans have varying degrees of sulfation, they may be studied comparatively for differences in protective, antiviral, and immunosuppression activities. Carrageenan may be used in the development of biomaterials such as bone graft substitutes; entrapping vessels such as biobeads and encapsulation vehicles for drug delivery. Carrageenan be used to develop hydrogels.
Carrageenans are used to suppress immune response in vivo and in vitro via mechanisms believed to involve selective cytopathic effect on macrophages. As ι-, κ-, and λ-carrageenans have varying degress of sulfation, they may be studied comparatively for differences in protective, antiviral, and immunosuppression activities.

Packaging

25, 100, 500 g in poly bottle
1 kg in poly bottle

Preparation Note

Blended from various seaweeds to produce rigid gels.

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Investigating ultrasound-light interaction in scattering media.
Huang, et al.
Journal of Biomedical Optics, 25, 1-12 (2020)
Ahu Uraz et al.
Journal of clinical and experimental dentistry, 5(1), e23-e29 (2014-01-24)
The objective of this study was to histologically and histomorphometrically evaluate the efficacy of the new formulations of eggshell-derived calcium carbonate in rats. The study was conducted on 30 adult male rats. Four standardized and circular intrabony defects were created...
José A Fernández-Romero et al.
Antimicrobial agents and chemotherapy, 56(1), 358-368 (2011-11-09)
Topical microbicides that block the sexual transmission of HIV and herpes simplex virus 2 (HSV-2) are desperately needed to reduce the incidence of HIV infections worldwide. Previously we completed phase 3 testing of the carrageenan-based gel Carraguard. Although the trial...
Immunopharmacology of the macrophage-toxic agent carrageenan.
A W Thomson et al.
International journal of immunopharmacology, 1(4), 247-261 (1979-01-01)
A W Thomson
Biomedicine / [publiee pour l'A.A.I.C.I.G.], 28(3), 148-152 (1978-05-01)
Since the biological effects of carrageenan were reviewed in 1972 by Di Rosa it has become clear from a large number of reports that this algal polysaccharide markedly influences immune responses. Profound suppression of immunity evidenced by impaired antibody production...

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