C113000

DMT-dC(ac) Phosphoramidite

≥99.0% (reversed phase HPLC)

• Synonym(s): DMT-dC(ac) Amidite, N-acetyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxycytidine, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite], N4-Acetyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxycytidine-3′-O-[O-(2-cyanoethyl)-N,N′-diisopropylphosphoramidite]
• Empirical Formula (Hill Notation): C₄₁H₅₀N₅O₈P
• CAS Number: 154110-40-4
• Molecular Weight: 771.84
• NACRES: NA.51
• PubChem Substance ID: 329774860
• UNSPSC Code: 12352200
• MDL number: MFCD09842112

Properties

• Product Name: DMT-dC(ac) Phosphoramidite, ≥99.0% (reversed phase HPLC)
• color: white to off-white
• InChI key: MECWEBCHRKVTNV-RLWDVSNXSA-N
• SMILES string: COc1ccc(cc1)C(OC[C@H]2O[C@H](C[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)N3C=CC(NC(C)=O)=NC3=O)(c4ccccc4)c5ccc(OC)cc5
• InChI: 1S/C41H50N5O8P/c1-28(2)46(29(3)4)55(52-25-11-23-42)54-36-26-39(45-24-22-38(43-30(5)47)44-40(45)48)53-37(36)27-51-41(31-12-9-8-10-13-31,32-14-18-34(49-6)19-15-32)33-16-20-35(50-7)21-17-33/h8-10,12-22,24,28-29,36-37,39H,11,25-27H2,1-7H3,(H,43,44,47,48)/t36-,37+,39+,55?/m0/s1
• biological source: non-animal source (no BSE/TSE risk)
• type: for DNA synthesis
• product line: Proligo Reagents
• assay: ≥98% (³¹P-NMR); ≥99.0% (reversed phase HPLC)
• form: powder
• mol wt: 771.85 g/mol
• packaging: pkg of 6 × 10 g C113000-6x10G (16 oz Bottle)
• technique(s): oligo synthesis: suitable
• solubility: water: insoluble
• λ: conforms (UV/VIS Identity)
• nucleoside profile: base: deoxycytidine; base protecting group: acetyl; 2' protecting group: none; 5' protecting group: DMT; deprotection: fast/standard
• storage temp.: -10 to -25°C
• Quality Level: 200

Description

Features and Benefits

Key Features of dC(ac):

• Ultrafast deprotection: 10 minutes at 65°C with AMA reagent
• Key component in oligonucleotide synthesis
• Industry standard for fast deprotection chemistry
• Operating for AMA deprotection methods without changes
• Consistent lot-to-lot high purity and performance
• Manufactured under a certified ISO 9001 quality system

General description

Proligo′s DNA phosphoramidites lead to high-yield and high-quality oligonucleotides due to their high coupling efficiency. The deprotection step of automated oligonucleotide synthesis is integral to synthesis time and final product quality. DMT-dC(ac) Phosphoramidite is an acetyl-protected DNA phosphoramidite used in fast deprotection chemistry for the rapid and high-yield synthesis of high-purity oligonucleotides. The product belongs to MerMade synthesizers.