C1188

Sigma-Aldrich

Collagen from bovine tracheal cartilage

Bornstein and Traub Type II, powder

CAS Number:
EC Number:
MDL number:
NACRES:
NA.61

Quality Level

biological source

bovine cartilage (tracheal)

form

powder

solubility

aqueous acid: soluble

storage temp.

2-8°C

Gene Information

cow ... COL2A1(407142)

General description

Collagen protein is abundantly present in human. It is the prime structural constituent of dermis. It is also an important constituent of extracellular matrix (ECM).
Collagen is classified into a number of structurally and genetically distinct types. We use the nomenclature proposed by Bornstein and Traub. Do not confuse Sigma type designations with recognized collagen classification types.

Application

Collagen from bovine tracheal cartilage has been used to induce arthritis in male DBA/1 mice. It has also been used as a fluorophore to acquire fluorescence emission spectra on the reflectance and fluorescence lifetime spectrometer (RFLS).
Collagen-type II has been investigated for its importance in haemostasis. Two peptides, CB8 and CB11, are sites of platelet binding and activation on collagen-type II. Collagen-type II has also been used as a model for arthritis in animals, where FR140423, a selective cyclooxygenase (COX)-2 inhibitor, has shown an anti-inflammatory effect without gastric lesions that may occur with treatment via indomethacin.

Collagen Type II is sometimes used to induce an animal model of rheumatoid arthritis. However, under conditions leading to formation of reactive oxygen species, the subjects develop tolerance for auto-antibodies. This is an unusual situation of ROS having a favorable effect.

Packaging

5 mg in glass bottle
10 mg in poly bottle

Biochem/physiol Actions

Collagen participates in the aging process. It offers a structural framework for cells and mechanical strength to tissues.

Preparation Note

Prepared by a modification of the pepsin extraction procedure of Trentham, et al., J. Exp. Med., 146, 857 (1977).

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Important role of interleukin-3 in the early phase of collagen-induced arthritis
Bruhl H, et al.
Arthritis and Rheumatism, 60(5), 1352-1361 (2009)
Molecular and cellular basis of hypertrophic scarring
Total Burn Care, 495-505 (2012)
Quantitative molecular sensing in biological tissues: an approach to non-invasive optical characterization
Chandra M, et al.
Optics Express, 14(13), 6157-6171 (2006)
Aging and the skin
Brocklehurst's Textbook of Geriatric Medicine and Gerontology, 133-137 (2010)
Malin Hultqvist et al.
Journal of immunology (Baltimore, Md. : 1950), 179(3), 1431-1437 (2007-07-21)
The view on reactive oxygen species (ROS) in inflammation is currently shifting from being considered damaging toward having a more complex role in regulating inflammatory reactions. We recently demonstrated a role of ROS in regulation of animal models for the...

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