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C1188

Sigma-Aldrich

Collagen from bovine tracheal cartilage

Bornstein and Traub Type II, powder

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CAS Number:
EC Number:
MDL number:
NACRES:
NA.61

biological source

bovine cartilage (tracheal)

Quality Level

form

powder

solubility

aqueous acid: soluble

UniProt accession no.

storage temp.

2-8°C

Gene Information

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C9301C5608C9879
Sigma-Aldrich

C5608

Collagen from rabbit skin

form

powder

form

powder

form

powder

form

powder

UniProt accession no.

P02459

UniProt accession no.

P02460

UniProt accession no.

Q28668

UniProt accession no.

P02459

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

aqueous acid: soluble

solubility

acetic acid: 0.5-2.0 mg/mL (Dissolve for several hours at 2-8 °C, occasionally swirling.)

solubility

aqueous acid: ≤10 mg/mL, aqueous sodium acetate buffer: soluble (0.01-0.5M)

solubility

-

Gene Information

cow ... COL2A1(407142)

Gene Information

chicken ... COL2A1(395069)

Gene Information

rabbit ... COL1A2(100008997)

Gene Information

bovine ... COL2A1(407142)

General description

Collagen protein is abundantly present in human. It is the prime structural constituent of dermis. It is also an important constituent of extracellular matrix (ECM).
Collagen is classified into a number of structurally and genetically distinct types. We use the nomenclature proposed by Bornstein and Traub. Do not confuse Sigma type designations with recognized collagen classification types.

Application

Collagen from bovine tracheal cartilage has been used to induce arthritis in male DBA/1 mice. It has also been used as a fluorophore to acquire fluorescence emission spectra on the reflectance and fluorescence lifetime spectrometer (RFLS).
Collagen-type II has been investigated for its importance in haemostasis. Two peptides, CB8 and CB11, are sites of platelet binding and activation on collagen-type II. Collagen-type II has also been used as a model for arthritis in animals, where FR140423, a selective cyclooxygenase (COX)-2 inhibitor, has shown an anti-inflammatory effect without gastric lesions that may occur with treatment via indomethacin.

Collagen Type II is sometimes used to induce an animal model of rheumatoid arthritis. However, under conditions leading to formation of reactive oxygen species, the subjects develop tolerance for auto-antibodies. This is an unusual situation of ROS having a favorable effect.

Biochem/physiol Actions

Collagen participates in the aging process. It offers a structural framework for cells and mechanical strength to tissues.

Preparation Note

Prepared by a modification of the pepsin extraction procedure of Trentham, et al., J. Exp. Med., 146, 857 (1977).

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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