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C1188

Sigma-Aldrich

Bovine Collagen Type II

from bovine tracheal cartilage, powder

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5 MG
$369.00
10 MG
$629.00

$369.00

Estimated to ship onJuly 07, 2025Details

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5 MG
$369.00
10 MG
$629.00

About This Item

CAS Number:
9007-34-5
EC Number:
232-697-4
MDL number:
MFCD00130825
UNSPSC Code:
12352202
NACRES:
NA.61

$369.00

Estimated to ship onJuly 07, 2025Details

Request a Bulk Order

Product Name

Collagen from bovine tracheal cartilage, Bornstein and Traub Type II, powder

biological source

bovine cartilage (tracheal)

Quality Level

200

form

powder

solubility

aqueous acid: soluble

UniProt accession no.

P02459

storage temp.

2-8°C

Gene Information

cow ... COL2A1(407142)

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Collagen from bovine tracheal cartilage Bornstein and Traub Type II, powder

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Collagen from calf skin Bornstein and Traub Type I, solid, BioReagent, suitable for cell culture

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Collagen from calf skin

Collagen Type IV from human cell culture Bornstein and Traub Type IV, 0.3 mg/mL, sterile-filtered, BioReagent, suitable for cell culture

C6745

Collagen Type IV from human cell culture

biological source

bovine cartilage (tracheal)

biological source

rabbit skin

biological source

bovine (calf) skin

biological source

human cell culture

form

powder

form

powder

form

solid

form

solution

solubility

aqueous acid: soluble

solubility

aqueous acid: ≤10 mg/mL, aqueous sodium acetate buffer: soluble (0.01-0.5M)

solubility

0.1 M acetic acid: 1 mg/mL (Allow to stir at room temperature 1-3 hours until dissolved.)

solubility

-

UniProt accession no.

P02459

UniProt accession no.

Q28668

UniProt accession no.

P02453

UniProt accession no.

P02462

Gene Information

cow ... COL2A1(407142)

Gene Information

rabbit ... COL1A2(100008997)

Gene Information

bovine ... COL1A1(282187)

Gene Information

human ... COL4A1(1282)

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

General description

Collagen is classified into a number of structurally and genetically distinct types. We use the nomenclature proposed by Bornstein and Traub. Do not confuse Sigma type designations with recognized collagen classification types.
Collagen protein is abundantly present in human. It is the prime structural constituent of dermis.[1] It is also an important constituent of extracellular matrix (ECM).[2]

Application

Collagen from bovine tracheal cartilage has been used to induce arthritis in male DBA/1 mice.[3] It has also been used as a fluorophore to acquire fluorescence emission spectra on the reflectance and fluorescence lifetime spectrometer (RFLS).[4]
Collagen-type II has been investigated for its importance in haemostasis. Two peptides, CB8 and CB11, are sites of platelet binding and activation on collagen-type II. Collagen-type II has also been used as a model for arthritis in animals, where FR140423, a selective cyclooxygenase (COX)-2 inhibitor, has shown an anti-inflammatory effect without gastric lesions that may occur with treatment via indomethacin.

Collagen Type II is sometimes used to induce an animal model of rheumatoid arthritis. However, under conditions leading to formation of reactive oxygen species, the subjects develop tolerance for auto-antibodies. This is an unusual situation of ROS having a favorable effect.[5]

Biochem/physiol Actions

Collagen participates in the aging process.[1] It offers a structural framework for cells and mechanical strength to tissues.[2]

Preparation Note

Prepared by a modification of the pepsin extraction procedure of Trentham, et al., J. Exp. Med., 146, 857 (1977).

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000447187
0000447187
0000431296
0000431296
0000384519

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