Currently, this product is of synthetic origin.
C1251
(+)-Catechin hydrate
≥98% (HPLC), antioxidant, powder
Synonym(s):
(+)-Cyanidol-3, (2R,3S)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol
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About This Item
Empirical Formula (Hill Notation):
C15H14O6 · xH2O
CAS Number:
Molecular Weight:
290.27 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
205-825-1
MDL number:
Beilstein/REAXYS Number:
3595244
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Product Name
(+)-Catechin hydrate, ≥98% (HPLC), powder
InChI key
OFUMQWOJBVNKLR-NQQJLSKUSA-N
InChI
1S/C15H14O6.H2O/c16-8-4-11(18)9-6-13(20)15(21-14(9)5-8)7-1-2-10(17)12(19)3-7;/h1-5,13,15-20H,6H2;1H2/t13-,15+;/m0./s1
SMILES string
[H]O[H].O[C@H]1Cc2c(O)cc(O)cc2O[C@@H]1c3ccc(O)c(O)c3
assay
≥98% (HPLC)
form
powder
color
yellow to yellow with tan cast
mp
175-177 °C (anhydrous) (lit.)
solubility
ethanol: 50 mg/mL
storage temp.
2-8°C
Quality Level
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Related Categories
1 of 4
This Item | |||
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥96.0% (sum of enantiomers, HPLC) | assay ≥96% (HPLC) | assay ≥97% (HPLC) |
| form powder | form powder | form powder | form powder |
| Quality Level 200 | Quality Level - | Quality Level 200 | Quality Level 200 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility ethanol: 50 mg/mL | solubility - | solubility - | solubility - |
| color yellow to yellow with tan cast | color - | color white to light brown | color - |
General description
Catechins are phytochemicals, richly present in black grapes, peaches, strawberries and broad beans. Catechins occur in various forms such as catechins, epicatechin, epicatechin gallate, epigallocatechin and epigallocatechin gallate.
Application
(+)-Catechin hydrate has been used:
- as a polyphenol standard in the determination of total polyphenols in the by-products of red wine
- as an additive to study its effects on in vitro methane production and substrate degradation in a triple-fed batch approach
- as a substrate to determine the activity of pure L. plantarum CECT 748T 14 recombinant tannase on catechin[1]
Biochem/physiol Actions
An antioxidant flavonoid of plant origin; a free radical scavenger, preventing free radical-mediated damage in a variety of biological systems. For example, at physiological pH catechin suppressed DNA strand breaks by hydroxyl radicals. It has also been shown to prevent human plasma oxidation. It delayed the consumption of endogenous lipid-soluble antioxidants and inhibited lipid oxidation. Catechin may also function as an inhibitor of fatty acid synthase.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Hadeer M Ezzat et al.
International journal of pharmaceutics, 565, 488-498 (2019-05-18)
Catechin hydrate is a phytopharmaceutical with promising anticancer effects but poor bioavailability. This study aimed to elaborate catechin loaded chitosan-tethered liposomes (chitosomes) to enhance catechin oral bioavailability. Nanocarriers were optimized via ethanol injection method followed by physicochemical, ex vivo and
Ana María García-Bores et al.
Saudi journal of biological sciences, 27(11), 3113-3124 (2020-10-27)
Verbesina crocata (Cav.) Less. (Arnica or Capitaneja) is an endemic plant from Mexico restricted to the western part of the country. The aerial parts are used in traditional medicine for the treatment of wounds and burns. The objective of this
S B Lotito et al.
Free radical biology & medicine, 24(3), 435-441 (1998-01-23)
Based on the recognized capacity of (+)-catechin (CTCH) to prevent free radical-mediated damage in different biological systems, its role in the protection of human plasma from oxidation was investigated. Samples of human blood plasma were incubated with 50 mM AAPH
Christine Ziegler et al.
Molecular microbiology, 78(1), 13-34 (2010-10-07)
Increases in the environmental osmolarity are key determinants for the growth of microorganisms. To ensure a physiologically acceptable level of cellular hydration and turgor at high osmolarity, many bacteria accumulate compatible solutes. Osmotically controlled uptake systems allow the scavenging of
Nutrition and Health Info Sheet: Catechins (2008)
Articles
Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.
Fatty acid synthesis supports cancer cell proliferation, essential for membrane generation, protein modification, and bioenergetics.
DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research
Protocols
Protocol for HPLC Analysis of Flavonoids on Ascentis® RP-Amide
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