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Sodium cholate hydrate

from bovine and/or ovine bile, ≥99%

3α,7α,12α-Trihydroxy-5β-cholan-24-oic acid sodium salt, Cholalic acid sodium salt
Empirical Formula (Hill Notation):
C24H39NaO5 · xH2O
CAS Number:
Molecular Weight:
430.55 (anhydrous basis)
EC Number:
MDL number:
PubChem Substance ID:

Quality Level

biological source

bovine and/or ovine bile





mol wt

micellar avg mol wt 900-1300

aggregation number



DNA purification: suitable
RNA purification: suitable
western blot: suitable


9-15 mM (20-25°C)



SMILES string




InChI key


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General description

Sodium cholate hydrate is a bio-surfactant which can be used as a reducing reagent in aqueous solution.


Sodium cholate hydrate has been used in a study to assess the effect of phospholipid formulation and surfactants on the dermal delivery of hydrophilic drugs from elastic liposomes. It has also been used in a study to investigate the elastic deformable vesicles, transfersomes, for transdermal drug delivery.
Non-denaturing detergent used for extraction of membrane proteins.


25, 100, 500 g in poly bottle
1 kg in poly bottle
5 kg in poly drum

Biochem/physiol Actions

Bile Salt

Storage Class Code

13 - Non Combustible Solids

WGK Germany


Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Yan Qiao et al.
Langmuir : the ACS journal of surfaces and colloids, 27(17), 11090-11097 (2011-07-19)
We report a facile method to synthesize water-soluble gold nanoparticles (AuNPs) using a biosurfactant sodium cholate as reducing reagents and protective groups in aqueous solution at ambient temperature. The diameters (13-70 nm) of uniform AuNPs can be readily adjusted by...
Transfersomes for transdermal drug delivery
Benson, H.
Expert Opinion on Drug Delivery, 3, 727-727 (2005)
Kevin B Ita et al.
The Journal of pharmacy and pharmacology, 59(9), 1215-1222 (2007-09-22)
The effect of phospholipid formulation and choice of surfactant on skin permeation of selected hydrophilic drugs from elastic liposomes across human epidermal membrane has been studied. Sodium cholate and various concentrations of phosphatidylcholine were used for the preparation of liposomes...
Ching-Wei Lin et al.
Nature communications, 10(1), 2874-2874 (2019-06-30)
Covalent doping of single-walled carbon nanotubes (SWCNTs) can modify their optical properties, enabling applications as single-photon emitters and bio-imaging agents. We report here a simple, quick, and controllable method for preparing oxygen-doped SWCNTs with desirable emission spectra. Aqueous nanotube dispersions...
Li Lei et al.
Current protocols in protein science, 84, 29-29 (2016-04-03)
Fish and human cytochrome P450 (P450) 17A1 catalyze both steroid 17α-hydroxylation and 17α,20-lyase reactions. Fish P450 17A2 catalyzes only 17α-hydroxylation. Both enzymes are microsomal-type P450s, integral membrane proteins that bind to the membrane through their N-terminal hydrophobic segment, the signal...


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Bile Acids

The liver excretes excess cholesterol in the form of bile acids. Bile acids serve two purposes: to remove unwanted cholesterol from the body and to aid in lipid digestion in the intestine.

Probiotics and Human Health

Today, diverse studies report the benefits of probiotics, such as inhibitory effects on pathogens, aid in the management or prevention of chronic intestinal inflammatory diseases or atopic syndromes, and support to the immune system. Potential beneficial applications abound, researchers continue to evaluate the effictiveness and clarify the mechanisms of action of probiotics.

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