C1386
Curcumin
from Curcuma longa (Turmeric), powder
Synonym(s):
(E,E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, Diferuloylmethane, Diferulylmethane, Natural Yellow 3
About This Item
Recommended Products
biological source
Curcuma longa (Turmeric)
Quality Level
vapor density
13 (vs air)
form
powder
concentration
≥65% (HPLC)
mp
175 °C
solubility
ethanol: 10 mg/mL
DMSO: >11 mg/mL (lit.)(lit.)
0.5 M NaOH: soluble (then immediately dilute in PBS [lit.])(lit.)
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
−20°C
SMILES string
COc1cc(\C=C\C(=O)CC(=O)\C=C\c2ccc(O)c(OC)c2)ccc1O
InChI
1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+
InChI key
VFLDPWHFBUODDF-FCXRPNKRSA-N
Gene Information
human ... APP(351) , CYP1A2(1544)
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General description
Application
- to study its effect on the consequences and mechanism involved in the suppression of human homeobox gene NKX3.1 in the prostate cancer cell LNCaP
- to examine its effect on stress in pigs by having an inhibitory impact on the serum cortisol concentration, hippocampal nitric oxide production, and brain-derived neurotrophic factor expression
- to study its effect as a dietary supplement on the growth, immunity, antioxidant activity, and disease resistance in Oreochromis niloticus
- to analyze its protective effect on the organotypic hippocampal slice cultures against the synaptic toxicity caused by amyloid beta peptides (Aβ1–42)
- to examine the possibility of its non-toxic concentrations to decrease the inflammation caused by interleukin-1beta (IL-1β) in cartilage explant cultures
- to study its protective impact against intestinal ischemia-reperfusion injury in rats
- to measure its antibacterial activity in vitro
- to determine its preventative effects for Alzheimer′s disease (AD) in mice
- as a bifunctional agent for generation and validation of the erythroid 2-related factor 2 (Nrf2) reporter system
- to study its in vitro inhibitory effects on human liver glucuronidation activity
- to evaluate its effects on Parkinson′s disease (PD)-like phenotypes
Biochem/physiol Actions
Features and Benefits
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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