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C1506

Sigma-Aldrich

Cytidine 5′-triphosphate disodium salt

≥95%

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Synonym(s):
CTP
Empirical Formula (Hill Notation):
C9H14N3Na2O14P3
CAS Number:
Molecular Weight:
527.12
EC Number:
MDL number:
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.77

Quality Level

assay

≥95%

form

powder

storage temp.

−20°C

SMILES string

[Na+].[Na+].NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]2O

InChI

1S/C9H16N3O14P3.2Na/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18;;/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18);;/q;2*+1/p-2/t4-,6-,7-,8-;;/m1../s1

InChI key

NFQMDTRPCFJJND-WFIJOQBCSA-L

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General description

Cytidine 5′-triphosphate is a nucleoside triphosphate with a pyrimidine ring. It is present in RNA.

Application

Cytidine 5′-triphosphate disodium salt has been used:
  • for the conversion of adenosine monophosphate (AMP) to adenosine diphosphate (ADP) in luminometry analysis
  • in the preparation of ribonucleotide 5′-triphosphate precursors stocks for large-scale RNA synthesis
  • to perform in vitro transcription

Biochem/physiol Actions

Cytidine 5′-triphosphate (CTP) prevents the action of aspartate carbamoyltransferase. This enzyme participates in pyrimidine biosynthesis. Like adenosine triphosphate (ATP), CTP serves as a molecule of high energy. It acts as a coenzyme in glycerophospholipid biosynthesis and protein glycosylation.
P2X4 purinergic receptor agonist.

Features and Benefits

This compound is featured on the P2 Receptors: P2X Ion Channel Family page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

wgk_germany

WGK 3

flash_point_f

235.4 °F

flash_point_c

113 °C

ppe

Eyeshields, Gloves, type N95 (US)


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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RNA synthesis using in vitro transcription by phage T7 RNA polymerase allows preparation of milligram quantities of RNA for biochemical, biophysical and structural investigations. Previous purification approaches relied on gel electrophoretic or gravity-flow chromatography methods. We present here a protocol

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