C1649

Sigma-Aldrich

Cardiolipin solution from bovine heart

4.7-5.3 mg/mL in ethanol, ≥97% (TLC)

EC Number:
MDL number:
NACRES:
NA.25

Quality Level

biological source

bovine heart

assay

≥97% (TLC)

form

liquid

concentration

4.7-5.3 mg/mL in ethanol

storage temp.

−20°C

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Biochem/physiol Actions

Cardiolipin is a mitochondrial phospholipid that is found in mammalian tissues in low concentrations. It is often a membrane component. Inhibits cell attachment of fibronectin, vitronectin and Type I collagen.

Other Notes

>80% polyunsaturated fatty acid content, primarily linoleic acid.

Physical form

Approximately 5 mg/ml in ethanol.

Pictograms

FlameExclamation mark

Signal Word

Danger

Hazard Statements

Precautionary Statements

RIDADR

UN1170 - class 3 - PG 2 - Ethanol, solution

WGK Germany

WGK 2

Flash Point(F)

57.2 °F - closed cup

Flash Point(C)

14 °C - closed cup

Certificate of Analysis

Certificate of Origin

Michael S Lee et al.
Cells, 9(4) (2020-04-25)
Mantle cell lymphoma (MCL) is an aggressive subtype of non-Hodgkin's lymphoma. Despite being responsive to combination chemotherapy, median survival remains around 5 years due to high rates of relapse. Sphingolipid metabolism regulates MCL survival and proliferation and we found that...
Denong Wang et al.
Drug development research, 75(3), 172-188 (2014-03-22)
Using an integrated antigen microarray approach, we observed epitope-spreading of autoantibody responses to a variety of antigenic structures in the cerebrospinal fluid (CSF) of patients with multiple sclerosis (MS) and in the serum of mice with experimental autoimmune encephalomyelitis (EAE)....
H A Schenkein et al.
Journal of dental research, 92(9), 814-818 (2013-07-17)
β2-glycoprotein I (β2GPI)-dependent anticardiolipin autoantibodies (aCl) are associated with thrombosis and fetal loss. Some microbial pathogens can induce pathogenic antibodies cross-reactive with β2GPI. Sera from a significant percentage of periodontitis patients contain aCl, and some periodontal pathogens contain antigens with...
Keun Young Hwang et al.
Journal of virology, 90(1), 506-520 (2015-10-30)
Mitochondrial lipid raft-like microdomains, experimentally also termed mitochondrial detergent-resistant membrane fractions (mDRM), play a role as platforms for recruiting signaling molecules involved in antiviral responses such as apoptosis and innate immunity. Viruses can modulate mitochondrial functions for their own survival...
Lidia Lancellotti et al.
Bioelectrochemistry (Amsterdam, Netherlands), 136, 107628-107628 (2020-08-17)
The Met80Ala and Met80Ala/Tyr67Ala variants of S. cerevisiae iso-1 cytochrome c (ycc) and their adducts with cardiolipin immobilized onto a gold electrode coated with a hydrophobic self-assembled monolayer (SAM) of decane-1-thiol were studied through cyclic voltammetry and surface-enhanced resonance Raman...

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