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C1649

Sigma-Aldrich

Cardiolipin solution from bovine heart

4.7-5.3 mg/mL in ethanol, ≥97% (TLC)

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Synonym(s):
Diphosphatidylglycerol solution
EC Number:
MDL number:
NACRES:
NA.25

biological source

bovine heart

Assay

≥97% (TLC)

form

liquid

packaging

glass bottle of

concentration

4.7-5.3 mg/mL in ethanol

color

colorless to yellow

functional group

phospholipid

lipid type

phosphoglycerides

shipped in

dry ice

storage temp.

−20°C

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This Item
SRE0029C0563M9004
assay

≥97% (TLC)

assay

≥97% (TLC)

assay

≥97% (TLC)

assay

-

form

liquid

form

liquid

form

lyophilized powder

form

ammonium sulfate suspension

concentration

4.7-5.3 mg/mL in ethanol

concentration

4.7-5.3 mg/mL in ethanol

concentration

-

concentration

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

Quality Level

300

Quality Level

400

Quality Level

200

Quality Level

200

General description

Cardiolipin (CL) is a complex lipid with a dimeric structure. It has four acyl chains and two phosphatidyl moieties. Its phosphatidyl moieties are linked to the glycerol backbone. Around 15-20 percent of the inner mitochondrial membrane accounts for cardiolipin.
Cardiolipin is a unique phospholipid found exclusively within the mitochondrial inner membrane. This specific localization allows Cardiolipin to exert crucial influence on mitochondrial structure and function. Deviations in Cardiolipin content, structure, or localization can lead to impaired mitochondrial activity, contributing to various diseases like cancer, neurological disorders, cardiovascular conditions, and metabolic diseases. As Cardiolipin plays a crucial role in mitochondrial function, it holds immense potential for biomarker development and finds application in cardiovascular, neuroscience, cancer, diabetes, and metabolomics research.

Application

Cardiolipin solution from bovine heart has been used:
  • for coating Corning 96-well enzyme immunoassay/radioimmunoassay (EIA/RIA) plate to perform enzyme-linked immunosorbent assay (ELISA)-based cardiolipin binding assay
  • in lipid analysis along with phosphatidylglycerol (PG) to comigrate the radiolabeled lipids to identify PG and cardiolipin (CL)
  • in coating ELISA plates for antiphospholipid antibodies (aPL) assays

Biochem/physiol Actions

Cardiolipin (CL) plays a key role in mitochondrial biogenesis, fusion and fission, respiration, and protein import. It participates in the cellular processes outside of the mitochondria like cell wall biogenesis, aging, vacuole homeostasis, the cell cycle, and apoptosis. CL is also involved in heart function, autophagy/mitophagy, and the protein kinase C (PKC) pathway.
Cardiolipin is a mitochondrial phospholipid that is found in mammalian tissues in low concentrations. It is often a membrane component and can inhibit cell attachment of fibronectin, vitronectin, and type I collagen.

Features and Benefits

  • High-quality molecule suitable for mulitple research applications
  • Commonly employed in Metabolomics and Biochemical studies

Other Notes

>80% polyunsaturated fatty acid content, primarily linoleic acid.

Physical form

Approximately 5 mg/ml in ethanol.

Pictograms

FlameExclamation mark

Signal Word

Danger

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

55.4 °F

Flash Point(C)

13 °C


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Michael S Lee et al.
Cells, 9(4) (2020-04-25)
Mantle cell lymphoma (MCL) is an aggressive subtype of non-Hodgkin's lymphoma. Despite being responsive to combination chemotherapy, median survival remains around 5 years due to high rates of relapse. Sphingolipid metabolism regulates MCL survival and proliferation and we found that
Denong Wang et al.
Drug development research, 75(3), 172-188 (2014-03-22)
Using an integrated antigen microarray approach, we observed epitope-spreading of autoantibody responses to a variety of antigenic structures in the cerebrospinal fluid (CSF) of patients with multiple sclerosis (MS) and in the serum of mice with experimental autoimmune encephalomyelitis (EAE).
Hervé Roy et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(12), 4667-4672 (2008-02-29)
Multiple peptide resistance (MprF) virulence factors control cellular permeability to cationic antibiotics by aminoacylating inner membrane lipids. It has been shown previously that one class of MprF can use Lys-tRNA(Lys) to modify phosphatidylglycerol (PG), but the mechanism of recognition and
H A Schenkein et al.
Journal of dental research, 92(9), 814-818 (2013-07-17)
β2-glycoprotein I (β2GPI)-dependent anticardiolipin autoantibodies (aCl) are associated with thrombosis and fetal loss. Some microbial pathogens can induce pathogenic antibodies cross-reactive with β2GPI. Sera from a significant percentage of periodontitis patients contain aCl, and some periodontal pathogens contain antigens with
Zheni Shen et al.
BioMed research international, 2015, 891707-891707 (2015-08-25)
Cardiolipin (CL), the signature phospholipid of mitochondrial membranes, is crucial for both mitochondrial function and cellular processes outside of the mitochondria. The importance of CL in cardiovascular health is underscored by the life-threatening genetic disorder Barth syndrome (BTHS), which manifests

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