The stability of this product in solution for extended periods has not been determined. Stock solutions stored in aliquots at -70°C are stable up to 6 months. Stock solutions may also be stored at -20°C, however no time frame has been established.
C1768
Cytarabine
≥90% (HPLC), crystalline, DNA replication inhibitor
Synonym(s):
(β-D-Arabinofuranosyl)cytosine, Ara-C, Arabinocytidine, Arabinosylcytosine, Cytarabine, Cytosine arabinoside
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100 MG
$50.40
500 MG
$180.00
1 G
$248.00
5 G
$805.80
About This Item
Empirical Formula (Hill Notation):
C9H13N3O5
CAS Number:
Molecular Weight:
243.22
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
205-705-9
MDL number:
Beilstein/REAXYS Number:
89175
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Product Name
Cytosine β-D-arabinofuranoside, crystalline, ≥90% (HPLC)
InChI key
UHDGCWIWMRVCDJ-CCXZUQQUSA-N
InChI
1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7+,8-/m1/s1
SMILES string
NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2O
assay
≥90% (HPLC)
form
crystalline
storage temp.
2-8°C
Quality Level
Gene Information
human ... POLA1(5422), POLA2(23649), POLB(5423), POLD1(5424), POLD2(5425), POLD3(10714), POLD4(57804), POLE(5426), POLE2(5427), POLE3(54107), PRIM1(5557), PRIM2(5558)
mouse ... Cda(72269)
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Related Categories
1 of 4
This Item | |||
|---|---|---|---|
| form crystalline | form - | form - | form crystalline |
| assay ≥90% (HPLC) | assay - | assay - | assay ≥99% (HPLC) |
| Quality Level 200 | Quality Level 300 | Quality Level - | Quality Level 200 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| Gene Information human ... POLA1(5422), POLA2(23649), POLB(5423), POLD1(5424), POLD2(5425), POLD3(10714), POLD4(57804), POLE(5426), POLE2(5427), POLE3(54107), PRIM1(5557), PRIM2(5558) | Gene Information human ... POLA1(5422), POLA2(23649), POLD1(5424), POLD2(5425), POLD3(10714), POLD4(57804), POLE(5426), POLE2(5427), POLE3(54107), PRIM1(5557), PRIM2(5558) | Gene Information human ... POLA1(5422), POLA2(23649), POLD1(5424), POLD2(5425), POLD3(10714), POLD4(57804), POLE(5426), POLE2(5427), POLE3(54107), PRIM1(5557), PRIM2(5558) | Gene Information human ... POLA1(5422), POLA2(23649), POLD1(5424), POLD2(5425), POLD3(10714), POLD4(57804), POLE(5426), POLE2(5427), POLE3(54107), PRIM1(5557), PRIM2(5558) |
Biochem/physiol Actions
Ara-C incorporates into DNA and inhibits DNA replication by forming cleavage complexes with topoisomerase I resulting in DNA fragmentation; does not inhibit RNA synthesis. Anti-leukemia agent.
Features and Benefits
This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
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Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
signalword
Danger
hcodes
Hazard Classifications
Muta. 1B - Repr. 2
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
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Hamed I Ali et al.
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Journal of medicinal chemistry, 54(16), 5937-5948 (2011-07-26)
Multidrug resistance (MDR) in cancer is a phenomenon in which administration of a single chemotherapeutic agent causes cross-resistance of cancer cells to a variety of therapies even with different mechanisms of action. Development of MDR against standard therapies is a
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Here we explore the applicability of the dipeptidyl peptidase IV (DPPIV/CD26) based prodrug approach to a variety of amine-containing drugs. Efficient procedures have been developed for the synthesis of dipeptide and tetrapeptide amide prodrugs including N-acylation protocols of the exocyclic
Sergio Amadori et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(35), 4424-4430 (2013-10-16)
This randomized trial evaluated the efficacy and toxicity of sequential gemtuzumab ozogamicin (GO) and standard chemotherapy in older patients with newly diagnosed acute myeloid leukemia (AML). Patients (n = 472) age 61 to 75 years were randomly assigned to induction
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Tosedostat is a novel oral aminopeptidase inhibitor with clinical activity in a previous phase 1-2 study in elderly patients with relapsed or refractory acute myeloid leukaemia (AML). We aimed to compare two dosing regimens of tosedostat. In this randomised phase
Articles
DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.
Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.
Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.
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How long could a solution of 2uM be stable at -80C? Would this storage help the aliquots last longer than a year at -20C?
1 answer-
Helpful?
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Hello, does the freeze-thaw cycle affect the potency or stability of cytarabine?
1 answer-
The freeze-thaw stability of this material in solution has not been determined. However, Cold Spring Harbor Protocols suggests solutions are stable for several weeks when refrigerated. For long term storage, store solutions in working aliquots at −20°C . Please see the link below to review this information:
https://cshprotocols.cshlp.org/content/2008/12/pdb.rec11555.full?text_only=trueHelpful?
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Does cytoine beta d arabinofuranoside (Arac) solution filterable by .22um filter ,, is it good idea to filter ara c
1 answer-
This product is soluble in water at 50 mg/mL and may be filter sterilized. It is recommended to use a low protein binding filter membrane, such as PES, to prevent product retention in the filter. Solution stability has not been determined, however, Cold Spring Harbor protocols suggest that the filtered stock solution may be stored refrigerated or frozen.
See the link below to review:
https://cshprotocols.cshlp.org/content/2008/12/pdb.rec11555.full?text_only=trueHelpful?
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