C2240

Anti-Calcium Channel Ca_V3.1 (α_1G) antibody produced in rabbit

Name: Anti-Calcium Channel Ca<SUB>V</SUB>3.1 (α<SUB>1G</SUB>) antibody produced in rabbit
Brand: SIGMA
Price: 389 USD
Availability: InStock

affinity isolated antibody, lyophilized powder

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50 μL

$389.00

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD04975325

Key Documents

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Product Name

Anti-Calcium Channel Ca_V3.1 (α_1G) antibody produced in rabbit, affinity isolated antibody, lyophilized powder

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

rat

technique(s)

western blot: 1:200 using rat brain membranes

UniProt accession no.

O54898

storage temp.

−20°C

target post-translational modification

unmodified

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This Item	C1868	C1241	C5613
Sigma-Aldrich C2240 Anti-Calcium Channel Ca_V3.1 (α_1G) antibody produced in rabbit	Sigma-Aldrich C1868 Anti-Calcium Channel Ca_V3.2 (α1H) antibody produced in rabbit	Sigma-Aldrich C1241 Anti-Calcium Channel Ca_V1.2 (human) antibody produced in rabbit	$Anti-Calcium Channel (α2/δSubunit) antibody produced in rabbit ~1 mg/mL, fractionated antiserum, buffered aqueous solution$ Sigma-Aldrich C5613 Anti-Calcium Channel (α₂/δSubunit) antibody produced in rabbit
Quality Level 100	Quality Level 200	Quality Level 200	Quality Level 200
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form fractionated antiserum
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
technique(s) western blot: 1:200 using rat brain membranes	technique(s) western blot: 1:200 using lysate from the ND7/23 cell line	technique(s) immunocytochemistry: suitable, western blot: 1:200 using rat heart membranes	technique(s) western blot: 5-10 μg/mL using rat brain tissue lysate

Application

Anti-Calcium Channel CaV3.1 (α_1G) antibody produced in rabbit is suitable for western blotting at a dilution of 1:200 using rat brain membranes.

Biochem/physiol Actions

CACNA1G (T-type channels) are involved in pacemaker activity, low-threshold calcium spikes, neuronal oscillations and resonance and rebound burst firing. It exhibits a significant window current that helps for Fe²⁺ pathway entry into cells with relevant concentrations of extracellular Fe²⁺. The window current also creates a pathway for Cd²⁺ entry into cells during Cd²⁺exposure. CACNA1G were found to be associated with Autism Spectrum Disorder.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Calcium channel, voltage-dependent, T type, α 1G subunit is a protein encoded by CACNA1G gene in humans. It belongs to a family of voltage-gated calcium channels and serves as the key transducer of cell surface membrane potential changes into local intracellular calcium transients that initiate many different physiological events.

Immunogen

peptide corresponding to amino acid residues 1-22 of rat Ca_V3.1. This epitope is highly homologous in human (20/22 residues identical).

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, and 0.05% sodium azide.

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Anti-Calcium Channel Ca_V3.2 (α1H) antibody produced in rabbit, affinity isolated antibody, lyophilized powder

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Molecular characterization of a neuronal low-voltage-activated T-type calcium channel.

E Perez-Reyes et al.

Nature, 391(6670), 896-900 (1998-03-12)

The molecular diversity of voltage-activated calcium channels was established by studies showing that channels could be distinguished by their voltage-dependence, deactivation and single-channel conductance. Low-voltage-activated channels are called 'T' type because their currents are both transient (owing to fast inactivation)

High-density SNP association study of the 17q21 chromosomal region linked to autism identifies CACNA1G as a novel candidate gene.

S P Strom et al.

Molecular psychiatry, 15(10), 996-1005 (2009-05-21)

Chromosome 17q11-q21 is a region of the genome likely to harbor susceptibility to autism (MIM(209850)) based on earlier evidence of linkage to the disorder. This linkage is specific to multiplex pedigrees containing only male probands (MO) within the Autism Genetic

Cd²⁺ block and permeation of CaV3.1 (α1G) T-type calcium channels: candidate mechanism for Cd²⁺ influx.

Kyle V Lopin et al.

Molecular pharmacology, 82(6), 1183-1193 (2012-09-14)

Cd²⁺ is an industrial pollutant that can cause cytotoxicity in multiple organs. We examined the effects of extracellular Cd²⁺ on permeation and gating of Ca(v)3.1 (α1G) channels stably transfected in HEK293 cells, by using whole-cell recording. With the use of

Fe²⁺ block and permeation of CaV3.1 (α1G) T-type calcium channels: candidate mechanism for non-transferrin-mediated Fe²⁺ influx.

Kyle V Lopin et al.

Molecular pharmacology, 82(6), 1194-1204 (2012-09-14)

Iron is a biologically essential metal, but excess iron can cause damage to the cardiovascular and nervous systems. We examined the effects of extracellular Fe²⁺ on permeation and gating of Ca(V)3.1 channels stably transfected in HEK293 cells, by using whole-cell

International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.

William A Catterall et al.

Pharmacological reviews, 57(4), 411-425 (2005-12-31)

The family of voltage-gated calcium channels serves as the key transducers of cell surface membrane potential changes into local intracellular calcium transients that initiate many different physiological events. There are 10 members of the voltage-gated calcium channel family that have

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Anti-Calcium Channel CaV3.1 (α1G) antibody produced in rabbit