Corticosterone is also soluble in DMSO at 69 mg/mL ( (199.15 mM). It is best to use a fresh stock bottle of DMSO that is deemed free of any moisture. Any contaminating moisture may accelerate the degradation of the compound in question or may render it insoluble. Please make sure the final concentration of DMSO in cell culture should not exceed more than 0.1%.
C2505
Corticosterone
≥92% (HPLC), powder, corticosteroid hormone
Synonym(s):
11β,21-Dihydroxy-4-pregnene-3,20-dione, 11β,21-Dihydroxyprogesterone, 4-Pregnene-11β,21-diol-3,20-dione, Kendall’s Compound B, Reichstein’s Substance H
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500 MG
$111.00
$111.00
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About This Item
Empirical Formula (Hill Notation):
C21H30O4
CAS Number:
Molecular Weight:
346.46
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
EC Number:
200-019-6
MDL number:
Beilstein/REAXYS Number:
2339601
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Product Name
Corticosterone, ≥92%
InChI
1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1
InChI key
OMFXVFTZEKFJBZ-HJTSIMOOSA-N
SMILES string
C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO
biological source
synthetic (organic)
assay
≥92%
form
powder
Quality Level
Gene Information
human ... EBP(10682), SERPINA6(866)
rat ... Ar(24208), Nr3c1(24413)
mp
179-183 °C (lit.)
solubility
chloroform: 50 mg/mL, clear, colorless to faintly yellow
shipped in
ambient
storage temp.
room temp
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Related Categories
1 of 4
This Item | |||
|---|---|---|---|
| assay ≥92% | assay ≥98.5% (HPLC) | assay ≥95% | assay ≥98% (HPLC) |
| form powder | form powder or crystals | form powder | form powder |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 300 |
| storage temp. room temp | storage temp. - | storage temp. room temp | storage temp. room temp |
| solubility chloroform: 50 mg/mL, clear, colorless to faintly yellow | solubility - | solubility chloroform: methanol (1:1): 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow | solubility water: 0.28 g/L at 25 °C |
| shipped in ambient | shipped in - | shipped in ambient | shipped in ambient |
Application
Biochem/physiol Actions
Corticosterone is a glucocorticoid secreted by the adrenal cortex that activates both mineralocorticoid and glucocorticoid receptors.
Corticosterone is synthesized from 11-deoxycortisone by the action of enzyme 11β-hydroxylase majorly in adrenal glands.[4] However, it may also be synthesized in non-adrenal tissues including leydig cells of testes[4] and in murine thymus.[5] Corticosterone is released post activation of hypothalamus-pituitary-adrenal (HPA) axis. It is a key player regulating metabolism, immune function and response to stress.[6] It is produced by HPA activation in response to stress in myeloid cells.[7] Elevated levels of corticosterone is observed in Huntington′s disease (HD).[8]
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Prenatal stress alters presynaptic marker proteins in the hippocampus of rat pups
Afadlal S, et al.
Neuroscience Letters, 470(1), 24-27 (2010)
Corticosterone production during repeated social defeat causes monocyte mobilization from the bone marrow, glucocorticoid resistance, and neurovascular adhesion molecule expression
Niraula A, et al.
The Journal of Neuroscience, 38(9), 2328-2340 (2018)
Somatostatin, neuronal vulnerability and behavioral emotionality
Lin LC and Sibille E
Molecular Psychiatry, 20(3), 377-377 (2015)
Amy E M Newman et al.
The Journal of comparative neurology, 518(18), 3662-3678 (2010-07-24)
Chronic elevations in glucocorticoids can decrease the production and survival of new cells in the adult brain. In rat hippocampus, supraphysiological doses of dehydroepiandrosterone (DHEA; a sex steroid precursor synthesized in the gonads, adrenals, and brain) have antiglucocorticoid properties. With
Glucocorticoid production in the chicken bursa and thymus
Lechner O, et al.
International Immunology, 13(6), 769-776 (2001)
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I tend to treat pc12 cell line with CORT C2505, and the question is how can I reconstitute the powder to be non-toxic to the cells? Because the chloroform or ethanol are toxic to the cells
1 answer-
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Which reagents should be used to dissolve product C2505, and what are the recommended storage conditions after it has been dissolved?
1 answer-
C2505 is soluble in Chloroform at 50 mg/mL, and should be colorless to faintly yellow in appearance.
Although we cannot provide any verified recommendations for temperature storage of solution, other literature sources suggest that the solution can remain at room temperature if the solution stays clear for 3 days. These sources suggest that it is soluble in ethanol at 50 mg/ml, and that following reconstitution, aliquot and freeze (-20°C), for stock solutions to be stable for up to 3 months (at -20°C). There are additional sources that recommend dissolving in acetone, methanol, ethanol (10 mM), chloroform, and DMSO (100 mM). It is insoluble in water.
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