Skip to Content
MilliporeSigma
All Photos(1)

Documents

C3042

Sigma-Aldrich

Corticotropin Releasing Factor human, rat

≥95% (HPLC), powder

Synonym(s):

CRF, CRH

Sign Into View Organizational & Contract Pricing


About This Item

Empirical Formula (Hill Notation):
C208H344N60O63S2
CAS Number:
Molecular Weight:
4757.45
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.32

biological source

human
rat

Quality Level

assay

≥95% (HPLC)

form

powder

mol wt

4757.45

storage condition

(Keep container tightly closed in a dry and well-ventilated place)

technique(s)

activity assay: suitable

solubility

water: 1.00-1.04 mg/mL, colorless

UniProt accession no.

storage temp.

−20°C

InChI key

VXFVFWFSJFSXHN-FAUHKOHMSA-N

Gene Information

human ... CRH(1392)

Looking for similar products? Visit Product Comparison Guide

Amino Acid Sequence

Ser-Glu-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Met-Glu-Ile-Ile-NH2

General description

The corticotropin-releasing factor is a 41-amino-acid polypeptide. It is expressed in neurons, the hypothalamus, and the amygdala.

Research area: Neuroscience

Application

Corticotropin Releasing Factor human, rat has been used:
  • as a component in Dulbecco′s modified eagle medium (DMEM) for incubating lung explants
  • as a component in serum-free complete medium for isolation and culturing of fetal distal lung epithelial cells
  • in the synthesis of the corticotropin-releasing factor(CRF)-TAMRA 1 mixture
  • in chronic intracerebroventicular administration, to study its effect on hypoxia in hippocampus

Biochem/physiol Actions

CRF is a hypothalamic peptide that releases ACTH and endorphin from the anterior pituitary. It is also a neurotransmitter in the central nervous system, and is involved in autonomic and endocrine responses to stress.
Corticotropin-releasing factor modulates stress responses. It facilitates stress-stimulated activation of the hypothalamic−pituitary−adrenal system.Corticotropin Releasing Factor/hormone (CRF/H) at higher levels has been observed in stress-related physiological and behavioral disorders. It has been involved in anxiety and depression disorders. Under stress conditions, the release of CRH activates the corticotrophin-releasing hormone receptor type I (CRHR1) in the anterior pituitary for the release of adrenocorticotropic hormone (ACTH) that further stimulates the production/secretion of cortisol/corticosterone.

Other Notes

Lyophilized from 0.1% TFA in H2O

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Frameworks of alcohol addiction: alcohol addiction as a reward deficit and stress surfeit disorder
Frontiers in Psychiatry, 3-28 (2014)
Transcriptional regulation of hypothalamic corticotropin-releasing factor gene
Vitamins & Hormones, 82, 301-317 (2010)
Salt appetite
Vitamins & Hormones (2017)
A Slominski
The British journal of dermatology, 160(2), 229-232 (2009-02-04)
Corticotropin-releasing hormone (CRH; previously known as corticotropin-releasing factor) is the central regulator of the hypothalamic-pituitary-adrenal (HPA) axis, which is the main organizer of the body’s response to stress.– Stress induces the hypothalamic production and release of CRH, which then causes
Expression of genes related to the hypothalamic-pituitary-adrenal axis in murine fetal lungs in late gestation
Simard M, et al.
Reproductive Biology and Endocrinology, 8(1), 134-134 (2010)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service