This product is not tested for biological activity.
C3042
Corticotropin Releasing Factor human, rat
≥95% (HPLC), powder
Synonym(s):
CRF, CRH
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0.1 MG
$244.00
250 μG
$415.65
0.5 MG
$837.00
About This Item
Empirical Formula (Hill Notation):
C208H344N60O63S2
CAS Number:
Molecular Weight:
4757.45
UNSPSC Code:
12352200
NACRES:
NA.32
MDL number:
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InChI key
VXFVFWFSJFSXHN-FAUHKOHMSA-N
biological source
human, rat
assay
≥95% (HPLC)
form
powder
mol wt
4757.45
storage condition
(Keep container tightly closed in a dry and well-ventilated place)
technique(s)
activity assay: suitable
solubility
water: 1.00-1.04 mg/mL, colorless
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
human ... CRH(1392)
1 of 4
This Item | |||
|---|---|---|---|
| biological source human, rat | biological source - | biological source - | biological source - |
| technique(s) activity assay: suitable | technique(s) - | technique(s) - | technique(s) - |
| assay ≥95% (HPLC) | assay ≥90% (HPLC) | assay ≥97% (HPLC) | assay ≥95% (HPLC) |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| form powder | form powder | form powder | form powder |
| UniProt accession no. | UniProt accession no. | UniProt accession no. - | UniProt accession no. - |
General description
The corticotropin-releasing factor is a 41-amino-acid polypeptide. It is expressed in neurons, the hypothalamus, and the amygdala.
Research area: Neuroscience
Research area: Neuroscience
Application
Corticotropin Releasing Factor human, rat has been used:
- as a component in Dulbecco′s modified eagle medium (DMEM) for incubating lung explants
- as a component in serum-free complete medium for isolation and culturing of fetal distal lung epithelial cells
- in the synthesis of the corticotropin-releasing factor(CRF)-TAMRA 1 mixture
- in chronic intracerebroventicular administration, to study its effect on hypoxia in hippocampus
Biochem/physiol Actions
CRF is a hypothalamic peptide that releases ACTH and endorphin from the anterior pituitary. It is also a neurotransmitter in the central nervous system, and is involved in autonomic and endocrine responses to stress.
Releases ACTH and endorphin from the anterior pituitary; central nervous system neurotransmitter.
Corticotropin-releasing factor modulates stress responses. It facilitates stress-stimulated activation of the hypothalamic−pituitary−adrenal system.Corticotropin Releasing Factor/hormone (CRF/H) at higher levels has been observed in stress-related physiological and behavioral disorders. It has been involved in anxiety and depression disorders.[1] Under stress conditions, the release of CRH activates the corticotrophin-releasing hormone receptor type I (CRHR1) in the anterior pituitary for the release of adrenocorticotropic hormone (ACTH) that further stimulates the production/secretion of cortisol/corticosterone.[2]
Other Notes
Lyophilized from 0.1% TFA in H2O
used together
Product No.
Description
Pricing
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Frameworks of alcohol addiction: alcohol addiction as a reward deficit and stress surfeit disorder
Frontiers in Psychiatry, 3-28 (2014)
Transcriptional regulation of hypothalamic corticotropin-releasing factor gene
Vitamins & Hormones, 82, 301-317 (2010)
Expression of genes related to the hypothalamic-pituitary-adrenal axis in murine fetal lungs in late gestation
Simard M, et al.
Reproductive Biology and Endocrinology, 8(1), 134-134 (2010)
A Slominski
The British journal of dermatology, 160(2), 229-232 (2009-02-04)
Corticotropin-releasing hormone (CRH; previously known as corticotropin-releasing factor) is the central regulator of the hypothalamic-pituitary-adrenal (HPA) axis, which is the main organizer of the body’s response to stress.– Stress induces the hypothalamic production and release of CRH, which then causes
Salt appetite
Vitamins & Hormones (2017)
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What is the solution stability of Corticotropin Releasing Factor human, rat (C3042)?
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Sigma has not tested Corticotropin Releasing Factor human, rat (C3042) for solution stability or for stability in culture. The following article looks at the stability of corticotropin releasing factor: Acta Med Okayama. 1985 Jun;39(3):199-206.
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What is the counter ion in Corticotropin Releasing Factor human, rat (C3042)?
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Corticotropin Releasing Factor human, rat (C3042) is lyophilized from 0.1% TFA in water.
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What is the difference between the peptide content and the purity of Corticotropin Releasing Factor human, rat (C3042)?
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The peptide content of Corticotropin Releasing Factor human, rat (C3042) is determined by amino acid analysis (AAA) and distinguishes how much of the product is actually peptide. The purity of Corticotropin Releasing Factor human, rat (C3042) is determined by HPLC and distinguishes how much of the peptide found is Corticotropin Releasing Factor human, rat (C3042).
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What is the solubility of Corticotropin Releasing Factor human, rat (C3042)?
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Based on our quality control testing, Corticotropin Releasing Factor human, rat (C3042) is soluble in water at a concentration of 1 mg/ml.
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