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C3660

Sigma-Aldrich

Complement C9 from human serum

≥150,000 C9H50 units/mg (using C9 deficient serum)

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CAS Number:
MDL number:
NACRES:
NA.61

biological source

human

Quality Level

assay

≥85% (SDS-GE)

form

solution

specific activity

≥150,000 C9H50 units/mg (using C9 deficient serum)

UniProt accession no.

application(s)

cell analysis

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... C9(735)

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This Item
C2910C3535C8195
Sigma-Aldrich

C3660

Complement C9 from human serum

Sigma-Aldrich

C2910

Complement C3 from human serum

Sigma-Aldrich

C3535

Complement C8 from human serum

Sigma-Aldrich

C8195

Complement C4 from human serum

biological source

human

biological source

human

biological source

human

biological source

human serum

form

solution

form

solution

form

solution

form

solution

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

UniProt accession no.

P02748

UniProt accession no.

P01024

UniProt accession no.

P07357

UniProt accession no.

P0C0L4

Gene Information

human ... C9(735)

Gene Information

human ... C3(718)

Gene Information

human ... C8A(731)

Gene Information

human ... C4A(720)

Application

Complement C9 from human serum is an essential part of the terminal complement system. It has been a topic in cancer research, where extracellular phosphorylation by ecto-PK of K562 cells on serine residues may serve as a protective mechanism against complement in tumor cells. Additionally, it can be used as a biomarker (in fucosylated form) for squamous cell lung cancer, as patients tend to show elevated levels of C9 protein.

Biochem/physiol Actions

Complement component C9 is the final component of the membrane attack complex (MAC) responsible for cell lysis by complement. CD59 binds to both C8 and C9 and prevents assembly of an active MAC, protecting cells against lytic activity.

Quality

Functionally pure by a sensitive hemolytic assay using deficient sera.

Physical form

Supplied as a solution in phosphate buffered saline, pH 7.2.

Other Notes

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable


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Phosphorylation of the complement component, C9, by an ecto-protein kinase of human leukemic cells
Paasa, Y., et al.
Immunopharmacology and Immunotoxicology, 42, 175-785 (1999)
Y Paas et al.
Archives of biochemistry and biophysics, 316(2), 780-788 (1995-02-01)
Ecto-protein kinases (ecto-PK), primarily of the serine/threonine kinase type, have been previously described on the surface of various normal, transformed, and tumor cells. We have found that in the presence of ATP and Mg2+, exogenously added substrates such as phosvitin
Yoshimitsu Kuwabara et al.
PloS one, 13(6), e0198472-e0198472 (2018-06-13)
Immunoproteomic analysis was performed to identify unknown, pathology-related molecules in patients with seronegative (SN) obstetric antiphospholipid syndrome (APS) who clinically satisfied the diagnostic criteria for APS, but not the serological criteria. We collected peripheral blood from 13 SN-APS outpatients with
Yuxiang Huang et al.
The Journal of biological chemistry, 281(37), 27398-27404 (2006-07-18)
CD59 is a membrane glycoprotein that regulates formation of the cytolytic membrane attack complex (MAC or C5b-9) on host cell membranes. It functions by binding to C8 (alpha chain) and C9 after their structural rearrangement during MAC assembly. Previous studies

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