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C4375

Sigma-Aldrich

N-Carbamyl-L-glutamic acid

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Synonym(s):
N-(aminocarbonyl)-L-glutamic acid
Empirical Formula (Hill Notation):
C6H10N2O5
CAS Number:
Molecular Weight:
190.15
MDL number:
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.26

Assay

≥98.0% (TLC)

form

powder

color

white

application(s)

cell analysis

storage temp.

2-8°C

SMILES string

NC(=O)N[C@@H](CCC(O)=O)C(O)=O

InChI

1S/C6H10N2O5/c7-6(13)8-3(5(11)12)1-2-4(9)10/h3H,1-2H2,(H,9,10)(H,11,12)(H3,7,8,13)/t3-/m0/s1

Inchi Key

LCQLHJZYVOQKHU-VKHMYHEASA-N

Gene Information

human ... CPS1(1373)

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1 of 4

This Item
PHR3819A0879G3640
Carglumic Acid certified reference material, pharmaceutical secondary standard

Supelco

PHR3819

Carglumic Acid

Glu-Glu

Sigma-Aldrich

G3640

Glu-Glu

form

powder

form

-

form

powder

form

powder

color

white

color

-

color

off-white to beige

color

white

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

Quality Level

200

Quality Level

300

Quality Level

200

Quality Level

200

application(s)

cell analysis

application(s)

pharmaceutical

application(s)

detection
peptide synthesis

application(s)

-

Biochem/physiol Actions

N-Carbamyl-L-glutamic acid (carglumic acid) is use to study its potential as a replacement therapy for N-acetylglutamate synthetase (NAGS) deficiency and to treat hyperammonemia.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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25G
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X D Liu et al.
Amino acids, 42(6), 2111-2119 (2011-06-04)
Placental vascular formation and blood flow are crucial for fetal survival, growth and development, and arginine regulates vascular development and function. This study determined the effects of dietary arginine or N-carbamylglutamate (NCG) supplementation during late gestation of sows on the
Nicholas Ah Mew et al.
Molecular genetics and metabolism, 98(4), 325-330 (2009-08-08)
We studied the effect on ureagenesis of a single dose of N-carbamylglutamate (NCG) in healthy young adults who received a constant infusion (300 min) of NaH(13)CO(3). Isotope ratio-mass spectrometry was used to measure the appearance of label in [(13)C]urea. At
Virginie Levrat et al.
Orphanet journal of rare diseases, 3, 2-2 (2008-02-01)
Hyperammonemia in patients with methylmalonic aciduria (MMA) and propionic aciduria (PA) is caused by accumulation of propionyl-CoA which decreases the synthesis of N-acetyl-glutamate, the natural activator of carbamyl phosphate synthetase 1. A treatment approach with carglumic acid, the structural analogue
X Wu et al.
Journal of animal science, 90 Suppl 4, 337-339 (2013-02-13)
To evaluate the effects of glutamate (Glu) or combination of Glu and N-carbamylglutamate (NCG) on intestinal mucosa morphology and epithelium cell proliferation, 18 piglets weaned at 21 d (BW 5.56 ± 0.51 kg) were grouped into 3 treatments and fed
Boris Gebhardt et al.
Molecular genetics and metabolism, 79(4), 303-304 (2003-09-02)
In patients with methylmalonic aciduria (MMA), the accumulating metabolite propiony-CoA results in an inhibition of the urea circle via the decreased synthesis of N-acetylglutamate, an essential activator of carbamylphosphat synthetase (CPS). This results in one of the major clinical problems

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