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MilliporeSigma

C4431

Sigma-Aldrich

Citrate-phosphate-dextrose solution with adenine

Synonym(s):

CPD-A

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50 ML
$41.40
10 X 50 ML
$304.00

$41.40


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About This Item

UNSPSC Code:
12161700
NACRES:
NA.25

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sterility

sterile-filtered

Quality Level

form

liquid

pH

5.4-6.7

storage temp.

2-8°C

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This Item
C7165C3821A2754
Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

300

form

liquid

form

liquid

form

liquid

form

powder

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

pH

5.4-6.7

pH

5.2-5.8

pH

4.5-5.5

pH

-

sterility

sterile-filtered

sterility

aseptically filled

sterility

sterile-filtered

sterility

-

General description

Citrate-phosphate-dextrose solution with adenine (CPDA) is an anticoagulant and preservative for storage of blood. It can prolong red blood cell storage life up to 35 days. It maintains platelet viability.[1] Usage of CPDA improves post-transfusion visibility and improves glucose and ATP levels in blood.[2]

Application

Citrate-phosphate-dextrose solution with adenine has been used as an anticoagulant during blood collection from cardiac puncture,[3] transgenic hen egg lysozyme-ovalbumin-Duffy (HOD) mice[4] and humans.[5]

Biochem/physiol Actions

Useful anticoagulant for whole blood
Recommended anticoagulant: whole blood ratio is 1:9

related product

Product No.
Description
Pricing

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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HyunJoo Park et al.
Scientific reports, 6, 34257-34257 (2016-10-05)
The functionality and viability of stored human red blood cells (RBCs) is an important clinical issue in transfusions. To systematically investigate changes in stored whole blood, the hematological properties of individual RBCs were quantified in blood samples stored for various
Krishnan MohanKumar et al.
Nature communications, 10(1), 3494-3494 (2019-08-04)
Necrotizing enterocolitis (NEC) is an idiopathic, inflammatory bowel necrosis of premature infants. Clinical studies have linked NEC with antecedent red blood cell (RBC) transfusions, but the underlying mechanisms are unclear. Here we report a neonatal murine model to investigate this
A monoclonal antibody against kininogen reduces inflammation in the HLA-B27 transgenic rat
Keith JC, et al.
Arthritis Research & Therapy, 7(4), R769-R769 (2005)
Taesik Go et al.
Scientific reports, 10(1), 8977-8977 (2020-06-04)
Digital holographic microscopy enables the recording of sample holograms which contain 3D volumetric information. However, additional optical elements, such as partially or fully coherent light source and a pinhole, are required to induce diffraction and interference. Here, we present a
James C Keith et al.
Arthritis research & therapy, 7(4), R769-R776 (2005-07-01)
The human leukocyte antigen B27 (HLA-B27) transgenic rat is a model of human inflammatory bowel disease, rheumatoid arthritis and psoriasis. Studies of chronic inflammation in other rat models have demonstrated activation of the kallikrein-kinin system as well as modulation by

Questions

1–4 of 4 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. I need to preserve PBMC in whole blood for a longer time that 8h from blood collection. This anticoagulant can help me to mantein not only red blood cells but also the other cellular type?

    1 answer
    1. The product should be suitable for use in preserving PBMCs (peripheral blood mononuclear cells) and other cell types in whole blood.

      Helpful?

  3. Hello, could you please provide the exact concentrations (in g/L or mM) of this CPDA solution? Specifically, how much of the following: citric acid, trisodium citrate dihydrate, sodium dihydrogen phosphate, dextrose, adenine? Thank you

    1 answer
    1. Unfortunately, this product's composition is proprietary. It is adapted from the American Association of Blood Banks Handbook (Technical Manual), 11th Ed., p. 52 and 53 (1993).

      Helpful?

  4. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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