C4710

Monoclonal Anti-Cyclin A antibody produced in mouse

Name: Monoclonal Anti-Cyclin A antibody produced in mouse
Brand: SIGMA
Price: 482.8 USD
Availability: InStock

clone CY-A1, ascites fluid

Slide 1 of 4

Select a Size

0.2 ML

$482.80

List Price$568.00Save 15%

Available to ship TODAYDetails

A recombinant, preservative-free antibody is available for your target. Try ZRB1590

Request a Bulk Order

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD00243105

Key Documents

View All Documentation

Product Name

Monoclonal Anti-Cyclin A antibody produced in mouse, clone CY-A1, ascites fluid

biological source

mouse

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

CY-A1, monoclonal

mol wt

antigen 60 kDa

contains

15 mM sodium azide

species reactivity

mouse, human, monkey, bovine

technique(s)

immunocytochemistry: suitable
microarray: suitable
western blot: 1:1,000 using a mouse NIH 3T3 cell extract

isotype

IgG2a

UniProt accession no.

P20248

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... CCNA2(890)
mouse ... Ccna2(12428)

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item	C7464	C8218	C8831
Sigma-Aldrich C4710 Monoclonal Anti-Cyclin A antibody produced in mouse	Sigma-Aldrich C7464 Monoclonal Anti-Cyclin D1 antibody produced in mouse	Sigma-Aldrich C8218 Monoclonal Anti-Cdk4 antibody produced in mouse	$Anti-Cyclin B1 antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution$ Sigma-Aldrich C8831 Anti-Cyclin B₁ antibody produced in rabbit
clone CY-A1, monoclonal	clone DCS-6, monoclonal	clone DCS-31, monoclonal	clone polyclonal
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
antibody form ascites fluid	antibody form ascites fluid	antibody form ascites fluid	antibody form IgG fraction of antiserum
Gene Information human ... CCNA2(890) mouse ... Ccna2(12428)	Gene Information human ... CCND1(595) mouse ... Ccnd1(12443) rat ... Ccnd1(58919)	Gene Information human ... CDK4(1019) mouse ... Cdk4(12567) rat ... Cdk4(94201)	Gene Information human ... CCNB1(891) mouse ... Ccnb1(268697)
biological source mouse	biological source mouse	biological source mouse	biological source rabbit
species reactivity mouse, human, monkey, bovine	species reactivity rat, mouse, human, monkey	species reactivity rat, mouse, human	species reactivity human, mouse, hamster

Application

Monoclonal Anti-Cyclin A antibody produced in mouse is suitable for:

immunocytochemistry
microarray
western blotting at a dilution of 1:1,000 using a mouse NIH 3T3 cell extract

Biochem/physiol Actions

The antibody recognizes an epitope present in amino acids 162-433 of bovine cyclin A. No cross-reactivity is detected with other cyclins (cyclin B, D, or E).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Cyclin A is a nuclear protein during S phase and it binds both cdk2 and cdc2. The availability of monoclonal antibody reacting specifically with cyclin A enables the subcellular detection and localization of cyclin A and the measurement of relative differences in cyclin A levels as a function of cell cycle phase.

Immunogen

recombinant bovine cyclin A.

Not finding the right product?

Try our Product Selector Tool.

related product

Product No.

Description

Pricing

ZRB1590

Anti-Cyclin A2 Antibody, clone 2K11 ZooMAb^® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells

Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Cyclin A2 modulates kinetochore-microtubule attachment in meiosis II.

Qing-Hua Zhang et al.

The Journal of cell biology, 216(10), 3133-3143 (2017-08-19)

Cyclin A2 is a crucial mitotic Cdk regulatory partner that coordinates entry into mitosis and is then destroyed in prometaphase within minutes of nuclear envelope breakdown. The role of cyclin A2 in female meiosis and its dynamics during the transition

Switch from p53 to MDM2 as differentiating human keratinocytes lose their proliferative potential and increase in cellular size.

J E Dazard et al.

Oncogene, 19(33), 3693-3705 (2000-08-19)

p53 transcription factor is mutated in most skin cell carcinomas and in more than 50% of all human malignancies. One of its transcriptional targets is MDM2, which in turn down-regulates p53. The role of the p53/MDM2 regulatory loop upon genotoxic

Transient association of MCM complex proteins with the nuclear matrix during initiation of mammalian DNA replication.

Emma L Hesketh et al.

Cell cycle (Georgetown, Tex.), 14(3), 333-341 (2015-02-07)

The minichromosome maintenance complex (MCM2-7) is the putative DNA helicase in eukaryotes, and essential for DNA replication. By applying serial extractions to mammalian cells synchronized by release from quiescence, we reveal dynamic changes to the sub-nuclear compartmentalization of MCM2 as

NOTCH1 mediates a switch between two distinct secretomes during senescence.

Matthew Hoare et al.

Nature cell biology, 18(9), 979-992 (2016-08-16)

Senescence, a persistent form of cell-cycle arrest, is often associated with a diverse secretome, which provides complex functionality for senescent cells within the tissue microenvironment. We show that oncogene-induced senescence is accompanied by a dynamic fluctuation of NOTCH1 activity, which

Chloroquine alleviates etoposide-induced centrosome amplification by inhibiting CDK2 in adrenocortical tumor cells.

T-Y Chen et al.

Oncogenesis, 4, e180-e180 (2015-12-23)

The antitumor drug etoposide (ETO) is widely used in treating several cancers, including adrenocortical tumor (ACT). However, when used at sublethal doses, tumor cells still survive and are more susceptible to the recurring tumor due to centrosome amplification. Here, we

View All Related Papers

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service