C4749

Carboxylesterase 2 human

Name: Carboxylesterase 2 human
Brand: SIGMA
Price: 671 USD

recombinant, expressed in mouse NSO cells, ≥95% (SDS-PAGE)

Synonym(s):

CES2, CES2A1

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10 μG

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About This Item

EC Number:

3.1.1.1 (BRENDA, IUBMB)

UNSPSC Code:

12352204

NACRES:

NA.54

Key Documents

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recombinant

expressed in mouse NSO cells

Quality Level

200

assay

≥95% (SDS-PAGE)

form

solution

specific activity

≥1.0 EU/μg
30,000 pmol/min-μg protein

mol wt

predicted mol wt ~60 kDa

concentration

0.4-0.6 mg/mL

impurities

≤1.0 EU/μg endotoxin

NCBI accession no.

NM_003869
NP_003860

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... CES2(8824)

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Show Differences

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This Item	SAB1406734	E0412	SAB1405606
Sigma-Aldrich C4749 Carboxylesterase 2 human	Sigma-Aldrich SAB1406734 Anti-CES2 antibody produced in mouse	Sigma-Aldrich E0412 Carboxylesterase 2 human	Sigma-Aldrich SAB1405606 Anti-CES1 antibody produced in mouse
Gene Information human ... CES2(8824)	Gene Information human ... CES2(8824)	Gene Information -	Gene Information human ... CES1(1066)
specific activity ≥1.0 EU/μg, 30,000 pmol/min-μg protein	specific activity -	specific activity ≥500 units/mg protein	specific activity -
assay ≥95% (SDS-PAGE)	assay -	assay -	assay -
form solution	form buffered aqueous solution	form liquid	form buffered aqueous solution
recombinant expressed in mouse NSO cells	recombinant -	recombinant expressed in baculovirus infected BTI insect cells	recombinant -
concentration 0.4-0.6 mg/mL	concentration -	concentration -	concentration -

Biochem/physiol Actions

Human carboxylesterase 2 (hCE-2) recognizes a substrate with a large alcohol group and small acyl group. Its substrate specificity may be restricted by a capability of acyl-hCE-2 conjugate formation due to the presence of conformational interference in the active site pocket. Carboxylesterases catalyze the biotransformation of several ester-containing drugs and prodrugs such as angiotensin-converting enzyme inhibitor (temocarpil, cilazapril), anti-tumor drugs (capecitabin) and narcotics.[1]

Member of a serine esterase family that hydrolyze ester and amide bonds. Carboxylesterase 2 is an endoplasmic reticulum-bound hydrolase that plays a critical role in xenobiotic detoxification and activation for ester-containing therapeutics. Carboxylesterase 2 is also involved in the detoxification of drugs such as heroin and cocaine. This enzyme is thought to play a role in lipid metabolism.

Physical form

Supplied as a solution containing sodium chloride, sodium acetate, and 20% glycerol.

Other Notes

One unit will cause the hydrolysis of 1 picomole of p-nitrophenylacetate per minute at pH 7.5 at 25 deg C.

pictograms

GHS08

signalword

Danger

hcodes

H334

pcodes

P261 - P284 - P501

Hazard Classifications

Resp. Sens. 1

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

0000444344

0000410311

0000361075

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Human carboxylesterase isozymes: catalytic properties and rational drug design.

Teruko Imai

Drug metabolism and pharmacokinetics, 21(3), 173-185 (2006-07-22)

Human carboxylesterase 1 (hCE-1, CES1A1, HU1) and carboxylesterase 2 (hCE-2, hiCE, HU3) are a serine esterase involved in both drug metabolism and activation. Although both hCE-1 and hCE-2 are present in several organs, the hydrolase activity of liver and small

Comparative analysis of selected biomarkers and pesticide sensitivity in juveniles of Solea solea and Solea senegalensis.

B Sànchez-Nogué et al.

Environmental science and pollution research international, 20(5), 3480-3488 (2012-12-06)

The common sole, Solea solea (Linneus, 1758), and the Senegalese sole, Solea senegalensis (Kaup, 1858), are two important commercial species that coexist in the NW Mediterranean. In order to assess the species' ability to respond to chemical insults, a comparison

Alteration of the expression of pesticide-metabolizing enzymes in pregnant mice: potential role in the increased vulnerability of the developing brain.

Marie C Fortin et al.

Drug metabolism and disposition: the biological fate of chemicals, 41(2), 326-331 (2012-12-12)

Studies on therapeutic drug disposition in humans have shown significant alterations as the result of pregnancy. However, it is not known whether pesticide metabolic capacity changes throughout pregnancy, which could affect exposure of the developing brain. We sought to determine

The functional G143E variant of carboxylesterase 1 is associated with increased clopidogrel active metabolite levels and greater clopidogrel response.

Joshua P Lewis et al.

Pharmacogenetics and genomics, 23(1), 1-8 (2012-11-01)

Carboxylesterase 1 (CES1) is the primary enzyme responsible for converting clopidogrel into biologically inactive carboxylic acid metabolites. We genotyped a functional variant in CES1, G143E, in participants of the Pharmacogenomics of Anti-Platelet Intervention (PAPI) study (n=566) and in 350 patients

Protein adducts as biomarkers of exposure to organophosphorus compounds.

Judit Marsillach et al.

Toxicology, 307, 46-54 (2012-12-25)

Exposure to organophosphorus (OP) compounds can lead to serious neurological damage or death. Following bioactivation by the liver cytochromes P450, the OP metabolites produced are potent inhibitors of serine active-site enzymes including esterases, proteases and lipases. OPs may form adducts

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