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C4835

Carcinoembryonic Antigen human

≥95% (SDS-PAGE), buffered aqueous solution

Synonym(s):

Cancer-associated CEA

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25 μg

Estimated to ship TODAYfromSAINT LOUIS

$330.00

About This Item

UNSPSC Code:
12352202
NACRES:
NA.32
MDL number:
MFCD00163225

$330.00

Estimated to ship TODAYDetails

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Quality Segment

200

assay

≥95% (SDS-PAGE)

form

buffered aqueous solution

UniProt accession no.

P06731

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... CEACAM5(1048)

General description

Carcinoembryonic antigen(CEA) or CEA cell adhesion molecule 5 (CEACAM5), is encoded by the gene mapped to human chromosome 19q13.2.[1] CEACAM5 is a member of the CEACAM family. This glycosylated protein contains a typical N-terminal variable immunoglobulin (Ig)-like domain, constant Ig-like domain, and a hydrophobic transmembrane domain with a glycosylphosphatidylinositol lipid moiety.[2]

Application

Carcinoembryonic Antigen human has been used as a standard in electrochemical immunosensor[3] and developed surface plasmon resonance imaging (SPRi) immunosensor.[4] It has also been used as a tumor-associated antigen (TAA) in enzyme-linked immunosorbent assay[5]

Biochem/physiol Actions

Carcinoembryonic antigen cell adhesion molecule 5 (CEACAM5) aids in cell adhesion and migration. In addition, this protein inhibits anoikis and thereby promoting tumorigenesis and metastasis. CEACAM5 is used as a biomarker to detect new cancer and cancer recurrence, particularly those with colorectal cancer. Upregulated expression of the gene enhances non-small-cell lung cancer (NSCLC) cell proliferation and invasion by regulating p38–Smad2/3 signaling. Therefore, CEACAM5 might be considered as an effective therapeutic target for treating NSCLC. Overexpression of the gene has also been observed in various types of cancer including gastrointestinal, pancreatic, and breast cancers.[2]

Packaging

Package size based on protein content

Physical form

Solution in 0.15 M phosphate buffered saline, pH 7.4, containing 0.1% sodium azide.

Analysis Note

Highly purified

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This Item
F6432C2331SRP0239
Carcinoembryonic Antigen human ≥95% (SDS-PAGE), buffered aqueous solution

Sigma-Aldrich

C4835

Carcinoembryonic Antigen human

FLT3 (571-993), active, GST tagged human PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sigma-Aldrich

F6432

FLT3 (571-993), active, GST tagged human

Monoclonal Anti-Carcinoembryonic Antigen antibody produced in mouse clone C6G9, ascites fluid

Sigma-Aldrich

C2331

Monoclonal Anti-Carcinoembryonic Antigen antibody produced in mouse

EGFR Active human recombinant, expressed in baculovirus infected insect cells, ≥70% (SDS-PAGE)

Sigma-Aldrich

SRP0239

EGFR Active human

description

≥95% (SDS-PAGE), buffered aqueous solution

description

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

description

clone C6G9, ascites fluid

description

recombinant, expressed in baculovirus infected insect cells, ≥70% (SDS-PAGE)

assay

≥95% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

assay

-

assay

≥70% (SDS-PAGE)

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

-

form

buffered aqueous solution

form

buffered aqueous glycerol solution

form

-

form

aqueous solution

UniProt accession no.

P06731

UniProt accession no.

P36888

UniProt accession no.

P13688

UniProt accession no.

P00533

storage temp.

−20°C

storage temp.

−70°C

storage temp.

−20°C

storage temp.

−70°C

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

flash_point_f

Not applicable

flash_point_c

Not applicable

Storage Class

12 - Non Combustible Liquids

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