C4859

Cycloheximide solution

Ready-Made Solution, microbial, 100 mg/mL in DMSO, 0.2 μm filtered

• Synonym(s): CHX
• Empirical Formula (Hill Notation): C₁₅H₂₃NO₄
• CAS Number: 66-81-9
• Molecular Weight: 281.35
• MDL number: MFCD00082346
• PubChem Substance ID: 24892732
• NACRES: NA.77

Properties

• Quality Level: 300
• biological source: microbial
• description: suitable for testing specifications (CHO C. growth inhibitor)
• sterility: 0.2 μm filtered
• form: solution
• concentration: 100 mg/mL in DMSO
• solubility: DMSO: soluble
• Mode of action: protein synthesis | interferes
• antibiotic activity spectrum: fungi; yeast
• storage temp.: 2-8°C
• SMILES string: O=C1[C@@]([C@H](O)CC2CC(NC(C2)=O)=O)([H])C[C@@H](C)C[C@@H]1C
• InChI: 1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1
• InChI key: YPHMISFOHDHNIV-FSZOTQKASA-N
• Gene Information: human ... FKBP1A(2280) , PIN1(5300)

Description

Specificity

Tested for cell growth arrest, selection of cycloheximide resistant yeast, apoptosis induction, and facilitation of apoptosis induction by FasL.

Packaging

1 mL in glass bottle

Biochem/physiol Actions

Cycloheximide (CHX) is an antibiotic produced by S. griseus. Its main biological activity is translation inhibition in eukaryotes resulting in cell growth arrest and cell death. CHX is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.Hygroscopic. Storage class (TRGS 510): Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials.

Safety Information

• Pictograms: GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H301 - H315 - H319 - H341 - H360D - H412
• Precautionary Statements: P201 - P202 - P273 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• RIDADR: UN 2810 6.1 / PGII
• WGK Germany: WGK 3
• Flash Point(F): 188.6 °F - closed cup
• Flash Point(C): 87 °C - closed cup