C4926

Calmodulin-dependent Protein Kinase II fragment 290-309

Name: Calmodulin-dependent Protein Kinase II fragment 290-309
Brand: SIGMA
Price: 729 USD
Availability: InStock

≥97% (HPLC)

Synonym(s):

CaM kinase II (290-309)

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1 MG

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About This Item

Empirical Formula (Hill Notation):

C₁₀₃H₁₈₅N₃₁O₂₄S

CAS Number:

115044-69-4

Molecular Weight:

2273.83

NACRES:

NA.32

PubChem Substance ID:

329775072

UNSPSC Code:

12352202

MDL number:

MFCD00076719

Assay:

≥97% (HPLC)

Key Documents

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InChI

1S/C103H185N31O24S/c1-17-58(10)80(98(154)131-75(50-57(8)9)97(153)133-82(63(15)136)100(156)134-81(62(14)135)99(155)126-72(39-46-159-16)92(148)127-73(48-55(4)5)93(149)119-61(13)101(157)158)132-84(140)59(11)117-79(138)53-116-86(142)66(33-21-25-40-104)122-95(151)74(49-56(6)7)128-90(146)68(35-23-27-42-106)124-89(145)71(38-30-45-115-103(112)113)125-88(144)70(37-29-44-114-102(110)111)120-83(139)60(12)118-94(150)77(52-78(109)137)130-96(152)76(51-64-31-19-18-20-32-64)129-91(147)69(36-24-28-43-107)123-87(143)67(34-22-26-41-105)121-85(141)65(108)47-54(2)3/h18-20,31-32,54-63,65-77,80-82,135-136H,17,21-30,33-53,104-108H2,1-16H3,(H2,109,137)(H,116,142)(H,117,138)(H,118,150)(H,119,149)(H,120,139)(H,121,141)(H,122,151)(H,123,143)(H,124,145)(H,125,144)(H,126,155)(H,127,148)(H,128,146)(H,129,147)(H,130,152)(H,131,154)(H,132,140)(H,133,153)(H,134,156)(H,157,158)(H4,110,111,114)(H4,112,113,115)/t58-,59-,60-,61-,62+,63+,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,80-,81-,82-/m0/s1

SMILES string

CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(O)=O

InChI key

LRKHMNPQPYICFK-RBGVSSEXSA-N

assay

≥97% (HPLC)

form

solid

composition

Peptide content, ≥70%

UniProt accession no.

Q13554, Q13555, Q13557, Q9UQM7

storage temp.

−20°C

Quality Level

200

Gene Information

human ... CAMK2A(815), CAMK2B(816), CAMK2D(817), CAMK2G(818)

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This Item	A4308	SAB4503244	SAB4503756
Sigma-Aldrich C4926 Calmodulin-dependent Protein Kinase II fragment 290-309	Sigma-Aldrich A4308 Autocamtide 2-related inhibitory peptide	Sigma-Aldrich SAB4503244 Anti-CAMK2 antibody produced in rabbit	Sigma-Aldrich SAB4503756 Anti-phospho-CaMK2 α/β/δ (pThr³⁰⁵) antibody produced in rabbit
assay ≥97% (HPLC)	assay ≥97% (HPLC)	assay -	assay -
Gene Information human ... CAMK2A(815), CAMK2B(816), CAMK2D(817), CAMK2G(818)	Gene Information human ... CAMK2A(815), CAMK2B(816), CAMK2D(817) mouse ... CAMK2A(12322), CAMK2B(12323), CAMK2D(108058) rat ... CAMK2A(25400), CAMK2B(24245), CAMK2D(24246)	Gene Information human ... CAMK2B(816)	Gene Information human ... CAMK2B(816), CAMK2D(817)
form solid	form lyophilized powder	form buffered aqueous solution	form buffered aqueous solution
UniProt accession no. Q13554, Q13557, Q13555, Q9UQM7	UniProt accession no. -	UniProt accession no. Q13554	UniProt accession no. Q13557
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
Quality Level 200	Quality Level 200	Quality Level 100	Quality Level 100

Biochem/physiol Actions

Potent Ca²⁺/calmodulin-dependent protein kinase II inhibitor.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Activation of calcium channels by cAMP in STC-1 cells is dependent upon Ca2+ calmodulin-dependent protein kinase II.

S Basavappa et al.

Biochemical and biophysical research communications, 254(3), 699-702 (1999-01-28)

Activation of L-type calcium channels in the neuroendocrine, cholecytstokinin-secreting cell line, STC-1, is vital for secretion of CCK. In the present study, the regulation of L-type Ca2+ channels by cAMP and Ca2+ calmodulin dependent protein kinase II (CaM-KII) in STC-1

Long-term potentiation is associated with an increased activity of Ca2+/calmodulin-dependent protein kinase II.

K Fukunaga et al.

The Journal of biological chemistry, 268(11), 7863-7867 (1993-04-15)

Among the molecular mechanisms that have been proposed to contribute to long-term potentiation in hippocampus are the activation and autophosphorylation of Ca2+/calmodulin-dependent protein kinase II (CaM kinase II). Here we report that high, but not low frequency stimulation applied to

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Calmodulin-dependent Protein Kinase II fragment 290-309