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C4926

Sigma-Aldrich

Calmodulin-dependent Protein Kinase II fragment 290-309

≥97% (HPLC)

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Synonym(s):
CaM kinase II (290-309)
Empirical Formula (Hill Notation):
C103H185N31O24S
CAS Number:
Molecular Weight:
2273.83
MDL number:
PubChem Substance ID:
NACRES:
NA.32

Quality Level

Assay

≥97% (HPLC)

form

solid

composition

Peptide content, ≥70%

UniProt accession no.

storage temp.

−20°C

SMILES string

CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(O)=O

InChI

1S/C103H185N31O24S/c1-17-58(10)80(98(154)131-75(50-57(8)9)97(153)133-82(63(15)136)100(156)134-81(62(14)135)99(155)126-72(39-46-159-16)92(148)127-73(48-55(4)5)93(149)119-61(13)101(157)158)132-84(140)59(11)117-79(138)53-116-86(142)66(33-21-25-40-104)122-95(151)74(49-56(6)7)128-90(146)68(35-23-27-42-106)124-89(145)71(38-30-45-115-103(112)113)125-88(144)70(37-29-44-114-102(110)111)120-83(139)60(12)118-94(150)77(52-78(109)137)130-96(152)76(51-64-31-19-18-20-32-64)129-91(147)69(36-24-28-43-107)123-87(143)67(34-22-26-41-105)121-85(141)65(108)47-54(2)3/h18-20,31-32,54-63,65-77,80-82,135-136H,17,21-30,33-53,104-108H2,1-16H3,(H2,109,137)(H,116,142)(H,117,138)(H,118,150)(H,119,149)(H,120,139)(H,121,141)(H,122,151)(H,123,143)(H,124,145)(H,125,144)(H,126,155)(H,127,148)(H,128,146)(H,129,147)(H,130,152)(H,131,154)(H,132,140)(H,133,153)(H,134,156)(H,157,158)(H4,110,111,114)(H4,112,113,115)/t58-,59-,60-,61-,62+,63+,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,80-,81-,82-/m0/s1

InChI key

LRKHMNPQPYICFK-RBGVSSEXSA-N

Gene Information

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This Item
A4308C9994SAB4503244
form

solid

form

lyophilized powder

form

buffered aqueous glycerol solution

form

buffered aqueous solution

UniProt accession no.

Q13554, Q13555, Q13557, Q9UQM7

UniProt accession no.

-

UniProt accession no.

Q13554

UniProt accession no.

Q13554

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−70°C

storage temp.

−20°C

Quality Level

200

Quality Level

-

Quality Level

200

Quality Level

-

Gene Information

human ... CAMK2A(815), CAMK2B(816), CAMK2D(817), CAMK2G(818)

Gene Information

human ... CAMK2A(815), CAMK2B(816), CAMK2D(817)
mouse ... CAMK2A(12322), CAMK2B(12323), CAMK2D(108058)
rat ... CAMK2A(25400), CAMK2B(24245), CAMK2D(24246)

Gene Information

human ... CAMK2B(816)

Gene Information

human ... CAMK2B(816)

Amino Acid Sequence

Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-Ala-Ile-Leu-Thr-Thr-Met-Leu-Ala

Biochem/physiol Actions

Potent Ca2+/calmodulin-dependent protein kinase II inhibitor.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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K Fukunaga et al.
The Journal of biological chemistry, 268(11), 7863-7867 (1993-04-15)
Among the molecular mechanisms that have been proposed to contribute to long-term potentiation in hippocampus are the activation and autophosphorylation of Ca2+/calmodulin-dependent protein kinase II (CaM kinase II). Here we report that high, but not low frequency stimulation applied to
S Basavappa et al.
Biochemical and biophysical research communications, 254(3), 699-702 (1999-01-28)
Activation of L-type calcium channels in the neuroendocrine, cholecytstokinin-secreting cell line, STC-1, is vital for secretion of CCK. In the present study, the regulation of L-type Ca2+ channels by cAMP and Ca2+ calmodulin dependent protein kinase II (CaM-KII) in STC-1

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